Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
12-7123-41 was used in Flow Cytometry to explore the use of virally-delivered interleukin 23 as an anti-cancer treatment.
Wed Aug 04 00:00:00 EDT 2021
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
12-7123-41 was used in Flow Cytometry to identify critical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloid-targeted immunotherapies currently undergoing clinical testing.
Thu Apr 16 00:00:00 EDT 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
12-7123-41 was used in Flow Cytometry to show IL-12 tethered to oncolytic vaccinia virus leading to transformed, immunogenic tumors and improved survival.
Sun Mar 01 00:00:00 EST 2020
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype.
Chen D,Xie J,Fiskesund R,Dong W,Liang X,Lv J,Jin X,Liu J,Mo S,Zhang T,Cheng F,Zhou Y,Zhang H,Tang K,Ma J,Liu Y,Huang B
Published figure using IL-12/IL-23 p40 monoclonal antibody (Product # 12-7123-41) in Flow Cytometry
Wed Feb 28 00:00:00 EST 2018
Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.
Cell host & microbe
Bouziat R,Biering SB,Kouame E,Sangani KA,Kang S,Ernest JD,Varma M,Brown JJ,Urbanek K,Dermody TS,Ng A,Hinterleitner R,Hwang S,Jabri B
12-7123-41 was used in Flow cytometry/Cell sorting to show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces TH1 immunity to dietary antigen.
Wed Nov 14 00:00:00 EST 2018
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
12-7123-41 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody.
Jobsri J,Allen A,Rajagopal D,Shipton M,Kanyuka K,Lomonossoff GP,Ottensmeier C,Diebold SS,Stevenson FK,Savelyeva N
12-7123 was used in Flow cytometry/Cell sorting to assess the effectiveness of a plant viral particle conjugate vaccine against a murine B-cell malignancy.
Mon Jan 25 00:00:00 EST 2016
IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing γδ T cells.
The Journal of investigative dermatology
Yoshiki R,Kabashima K,Honda T,Nakamizo S,Sawada Y,Sugita K,Yoshioka H,Ohmori S,Malissen B,Tokura Y,Nakamura M
12-7123 was used in Flow cytometry/Cell sorting to clarify the role of Langerhans cells in psoriasis.
Tue Jul 01 00:00:00 EDT 2014
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
12-7123 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.
Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH
12-7123 was used in Flow cytometry/Cell sorting to show that macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentum.
Tue Jan 01 00:00:00 EST 2013
Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice.
Donners MM,Wolfs IM,Stöger LJ,van der Vorst EP,Pöttgens CC,Heymans S,Schroen B,Gijbels MJ,de Winther MP
12-7123 was used in Flow cytometry/Cell sorting to investigate the role of miR155 in atherosclerosis in vivo, showing that miR155 deficiency enhances atherosclerosis and decreases plaque stability.
Thu Sep 13 00:00:00 EDT 2012
Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Lu H,Yang Y,Gad E,Wenner CA,Chang A,Larson ER,Dang Y,Martzen M,Standish LJ,Disis ML
12-7123 was used in Flow cytometry/Cell sorting to demonstrate that polysaccharide krestin is a specific TLR2 agonist and has potent antitumor effects.
Sat Jan 01 00:00:00 EST 2011
Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation.
Alcoholism, clinical and experimental research
Fan J,Edsen-Moore MR,Turner LE,Cook RT,Legge KL,Waldschmidt TJ,Schlueter AJ
12-7123 was used in Flow cytometry/Cell sorting to assess the functional capability of ethanol-exposed dendritic cells, using a murine model of chronic alcohol abuse.
Sat Jan 01 00:00:00 EST 2011
Distinct roles for MyD88 and Toll-like receptor 2 during Leishmania braziliensis infection in mice.
Infection and immunity
Vargas-Inchaustegui DA,Tai W,Xin L,Hogg AE,Corry DB,Soong L
12-7123 was used in Flow cytometry/Cell sorting to investigate whether TLRs are involved in L. braziliensis-mediated dendritic cell activation, showing distinct roles for MyD88 and TLR2 in infection.
Wed Jul 01 00:00:00 EDT 2009
Role of interleukin-1beta in activating the CD11c(high) CD45RB- dendritic cell subset and priming Leishmania amazonensis-specific CD4+ T cells in vitro and in vivo.
Infection and immunity
Xin L,Li Y,Soong L
12-7123 was used in Flow cytometry/Cell sorting to investigate the mechanism by which the Leishmania amazonensis parasite modulates antigen-presenting cells and disrupts the immune system.
Mon Oct 01 00:00:00 EDT 2007