This antibody is predicted to react with human, mouse and rat based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
IL-35, or Interleukin 35 is a cytokine belonging to the IL12 family, that is produced by regulatory T cells. It is a dimeric protein composed of IL-12-alpha and IL-27-beta chains. Members of this class of cytokines are important in influencing T helper cell differentiation and supressing inflammatory response. IL-35 is known to induce proliferation of regulatory T cells, and reduce the activity of helper Th17 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 35 kD subunit; CLMF; CLMF p35; cytotoxic lymphocyte maturation factor 1; cytotoxic lymphocyte maturation factor 1, p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12; IL-12 subunit p35; IL-12, subunit p35; IL-12A; IL12p35; IL35 subunit; interleukin 12; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 alpha chain; Interleukin-12 subunit alpha; natural killer cell stimulatory factor 1; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NKSF1; subunit p35
Gene Aliases: CLMF; IL-12A; IL12A; NFSK; NKSF1; P35