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Invitrogen

IL-12 p70 Monoclonal Antibody (CC301)

View all (26) IL-12 p70 antibodies

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Product Details

MA5-16618

Applications
Tested Dilution
Publications

Western Blot (WB)

1:50-1:100
-

Flow Cytometry (Flow)

1:10
-

ELISA (ELISA)

8 µg/mL
-

Functional Assay (Functional)

1:100
-
Product Specifications

Species Reactivity

Bovine, Human, Sheep

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

CC301

Immunogen

Recombinant bovine IL-12

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

500 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538116

Product Specific Information

This antibody does not react with mouse.

Membrane permeabilization is required for flow cytometry applications. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01 EU/ug.

Mouse anti Bovine Interleukin-12/23 antibody, clone CC301 recognizes the p40 subunit of bovine interleukin-12, and binds to both the free subunit and the intact heterodimer.

Target Information

IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 20C2; CLMF p35; CLMF p40; cytokine; cytotoxic lymphocyte maturation factor 1, p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; IL-12; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12, subunit p35; Il-12; cytokine; IL-12A; IL-12B; IL12; IL12, subunit p40; IL12A/B; IL12AB; IL35 subunit; ILN; Interleukin; interleukin 12 35kDa subunit; interleukin 12 40kDa subunit; interleukin 12 polypeptide 35; interleukin 12, p35; interleukin 12, p40; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 alpha chain; interleukin-12 beta chain; interleukin-12 p40 subunit; Interleukin-12 p70; Interleukin-12 subunit alpha; Interleukin-12 subunit beta; MGC151228; MGC151232; natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35; natural killer cell stimulatory factor 2; cytotoxic lymphocyte maturation factor 2; IL12p40; natural killer cell stimulatory factor, 40 kD subunit; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NK cell stimulatory factor chain 2; NKSF/CLMF; IL12p35; 35kD; NKSF/CLMF; IL12p40; 40kD; NKSF1; NKSF2

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Gene Aliases: CLMF; CLMF2; IL-12; Il-12 p35; IL-12A; IL-12B; IL12; IL12A; IL12B; IL12P35; IL12p40; IMD28; IMD29; NFSK; NKSF; NKSF1; NKSF2; P35

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UniProt ID: (Sheep) Q9TU27, (Human) P29459, (Bovine) P54349, (Human) P29460, (Sheep) P68220, (Bovine) P46282

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Entrez Gene ID: (Sheep) 443064, (Human) 3592, (Bovine) 281856, (Human) 3593, (Sheep) 443472, (Bovine) 281857

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Function(s)
cytokine activity interleukin-12 receptor binding protein binding growth factor activity interleukin-12 beta subunit binding interleukin-27 binding protein heterodimerization activity cytokine receptor activity cytokine receptor binding interleukin-12 alpha subunit binding identical protein binding macromolecular complex binding interleukin-23 receptor binding transmembrane signal receptor
Process(es)
positive regulation of T cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response response to virus response to UV-B cell migration response to lipopolysaccharide negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of natural killer cell activation positive regulation of mononuclear cell proliferation positive regulation of smooth muscle cell apoptotic process interleukin-12-mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein T-helper 1 cell differentiation positive regulation of cell adhesion positive regulation of natural killer cell mediated cytotoxicity negative regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation negative regulation of protein secretion defense response to Gram-positive bacterium positive regulation of NK T cell activation extrinsic apoptotic signaling pathway cellular response to virus negative regulation of vascular endothelial growth factor signaling pathway negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of dendritic cell chemotaxis signal transduction natural killer cell activation interferon-gamma production T-helper cell differentiation positive regulation of activated T cell proliferation regulation of cytokine production positive regulation of leukocyte mediated cytotoxicity positive regulation of defense response to virus by host natural killer cell activation involved in immune response positive regulation of lymphocyte mediated immunity positive regulation of T-helper 1 type immune response negative regulation of inflammatory response to antigenic stimulus cell surface receptor signaling pathway JAK-STAT cascade cell proliferation negative regulation of interleukin-10 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation positive regulation of tissue remodeling T-helper 1 type immune response T cell proliferation positive regulation of T cell proliferation T cell activation defense response to protozoan positive regulation of memory T cell differentiation positive regulation of osteoclast differentiation oocyte development regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium positive regulation of NK T cell proliferation defense response to virus cellular response to lipopolysaccharide cellular response to interferon-gamma positive regulation of NIK/NF-kappaB signaling positive regulation of T-helper 17 type immune response positive regulation of T-helper 17 cell lineage commitment
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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