|Tested species reactivity||Rat|
|Published species reactivity||Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant rat IL-13.|
|Storage buffer||PBS, pH 7.2|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
IL-13 is a cytokine involved in regulating inflammatory and immune responses. It down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Rat||Not Cited||Trichinella spiralis infection rapidly induces lung inflammatory response: the lung as the site of helminthocytotoxic activity.||Gentilini MV,Nuñez GG,Roux ME,Venturiello SM||Immunobiology (216:1054)||2011|
|Rat||Not Cited||Interleukin-25 and interleukin-13 production by alveolar macrophages in response to particles.||Kang CM,Jang AS,Ahn MH,Shin JA,Kim JH,Choi YS,Rhim TY,Park CS||American journal of respiratory cell and molecular biology (33:290)||2005|