|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Rat / IgG1|
|Immunogen||Purified recombinant human IL-13|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
IL-13 is a cytokine involved in regulating inflammatory and immune responses. It down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Variation of T-cell activation in allergic subjects during natural pollen exposure.
AHC0132 was used in flow cytometry to compare the Th1/Th2 balance in cypress allergic patients with controls
|Koscher V,Milhe F,El Biaze M,Vervloet D,Magnan A||Allergy (61:35)||2006|
Assessment of T lymphocyte cytokine production in induced sputum from asthmatics: a flow cytometry study.
AHC0132 was used in immunocytochemistry to measure T cell cytokine production in induced sputum.
|Boniface S,Koscher V,Mamessier E,El Biaze M,Dupuy P,Lorec AM,Guillot C,Badier M,Bongrand P,Vervloet D,Magnan A||Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (33:1238)||2003|