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Intracellular staining of 3-day Th17-polarized splenocytes treated with Brefeldin A (left) or restimulated with PMA/Ionomycin in the presence of Brefeldin A (right) with Anti-Mouse CD4 FITC and 0.015 ug of Anti-Mouse/Rat IL-17A PerCP-Cy5.5 (cat. no. A14804). Cells in the lymphocyte gate were used for analysis.
|Tested species reactivity||Mouse, Rat|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rat / IgG2a|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation.
A14804 was used in flow cytometry to characterize attenuation of airway obliteration in rat orthotopic tracheal transplantation by Anti-IL-23 antibody blockade of IL-23/IL-17 pathway
|Cao H,Lan Q,Shi Q,Zhou X,Liu G,Liu J,Tang G,Qiu C,Qiu C,Xu J,Fan H,Liu Z||International immunopharmacology (11:569)||2011|
CTLA-8; CTLA8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated serine esterase 8; IL-17; IL17; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); Interleukin-17A
CTLA-8; Ctla8; IL-17; IL-17A; Il17; Il17a