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Intracellular staining of 3-day Th17-polarized splenocytes treated with Brefeldin A (left) or restimulated with PMA/Ionomycin in the presence of Brefeldin A (right) with Anti-Mouse CD4 FITC and 0.015 ug of Anti-Mouse/Rat IL-17A PerCP-Cy5.5 (cat. no. A14804). Cells in the lymphocyte gate were used for analysis.
|Tested species reactivity||Mouse , Rat|
|Host / Isotype||Rat / IgG2a|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CTLA-8, IL-17, Ctla8, IL-17A, Il17, Ctla-8
Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), cytotoxic T-lymphocyte-associated antigen 8, interleukin-17A, CTLA8, IL17, interleukin 17, cytotoxic T-lymphocyte-associated serine esterase 8, Interleukin-17A