Post-transplant cyclophosphamide prevents xenogeneic graft-versus-host disease while depleting proliferating regulatory T cells.
Ritacco C,Köse MC,Courtois J,Canti L,Beguin C,Dubois S,Vandenhove B,Servais S,Caers J,Beguin Y,Ehx G,Baron F
17-7179-42 was used in Flow cytometry/Cell sorting to demonstrated that highly xenoreactive T-cell clones were depleted by PTCy. Although Treg frequencies were significantly higher in PTCy-treated than in control mice on day 21, xGVHD attenuation by PTCy was not abrogated by Treg depletion.
Fri Mar 17 00:00:00 EDT 2023
Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects.
Ehx G,Fransolet G,de Leval L,D'Hondt S,Lucas S,Hannon M,Delens L,Dubois S,Drion P,Beguin Y,Humblet-Baron S,Baron F
17-7179 was used in Flow cytometry/Cell sorting to investigate the impact of 5-azacytidine on xenogeneic graft-vs.-host disease and graft-vs.-leukaemia effects in a humanised murine model of transplantation.
Tue Jan 12 00:00:00 EST 2021
Chronic morphine administration differentially modulates viral reservoirs in SIVmac251 infected rhesus macaque model.
Journal of virology
Acharya A,Olwenyi OA,Thurman M,Pandey K,Morsey BM,Lamberty B,Ferguson N,Callen S,Fang Q,Buch SJ,Fox HS,Byrareddy SN
17-7179-42 was used in Flow Cytometry to suggest that people with HIV who abuse opioids had higher reservoirs in CNS than the lymphoid system.
Wed Dec 16 00:00:00 EST 2020
Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells.
Lee M,Lee E,Han SK,Choi YH,Kwon DI,Choi H,Lee K,Park ES,Rha MS,Joo DJ,Shin EC,Kim S,Kim JK,Lee YJ
17-7179 was used in Flow cytometry/Cell sorting to indicate that innate T cells share effector differentiation processes in the thymus.
Mon Aug 31 00:00:00 EDT 2020
Tumors induce de novo steroid biosynthesis in T cells to evade immunity.
Mahata B,Pramanik J,van der Weyden L,Polanski K,Kar G,Riedel A,Chen X,Fonseca NA,Kundu K,Campos LS,Ryder E,Duddy G,Walczak I,Okkenhaug K,Adams DJ,Shields JD,Teichmann SA
17-7179 was used in Flow cytometry/Cell sorting to show that tumors induce de novo steroidogenesis in T lymphocytes to evade anti-tumor immunity.
Fri Jul 17 00:00:00 EDT 2020
Respiratory Syncytial Virus Infection Reduces Kynurenic Acid Production and Reverses Th17/Treg Balance by Modulating Indoleamine 2,3-Dioxygenase (IDO) Molecules in Plasmacytoid Dendritic Cells.
Medical science monitor : international medical journal of experimental and clinical research
Jin L,Hu Q,Hu Y,Chen Z,Liao W
17-7179 was used in Flow cytometry/Cell sorting to understand that respiratory syncytial virus infection reduces the production of kynurenic acid and inhibits transformation from Th17 to Foxp3+ regulatory T cells by modulating indoleamine 2,3-dioxygenase molecules in plasmacytoid dendritic cells.
Wed Dec 02 00:00:00 EST 2020
IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b.
Cell death & disease
Yang R,Huang H,Cui S,Zhou Y,Zhang T,Zhou Y
17-7179-42 was used in Flow Cytometry to investigate the potential anti-inflammatory effects of bone marrow mesenchymal stem cell-derived exosomes.
Thu Jul 30 00:00:00 EDT 2020
Interleukin-24 Regulates T Cell Activity in Patients With Colorectal Adenocarcinoma.
Frontiers in oncology
Zhang Y,Liu Y,Xu Y
17-7179-42 was used in Flow Cytometry to indicate that IL-24 might regulate T cell function in a dose-dependent manner.
Wed Sep 30 00:00:00 EDT 2020
Two phase kinetics of the inflammatory response from hepatocyte-peripheral blood mononuclear cell interactions.
Beringer A,Molle J,Bartosch B,Miossec P
17-7179 was used in Flow cytometry/Cell sorting to study the role of interactions between non and activated human peripheral blood mononuclear cells and human hepatoma HepaRG cells in the inflammatory response.
Mon Jun 10 00:00:00 EDT 2019
CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS).
Clinical immunology (Orlando, Fla.)
Li MM,Zhang WJ,Weng XF,Li MY,Liu J,Xiong Y,Xiong SE,Zou CC,Wang H,Lu MJ,Yang DL,Peng C,Zheng X
17-7179 was used in Flow cytometry/Cell sorting to indicate that CD4 T-cell deficiency, Th2 and Th17 bias were closely correlated with the severity of SFTS, indicating therapeutic potential of early immune interventions to ameliorate disease severity.
Mon Oct 01 00:00:00 EDT 2018
The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway.
Science translational medicine
Wen Z,Shen Y,Berry G,Shahram F,Li Y,Watanabe R,Liao YJ,Goronzy JJ,Weyand CM
17-7179 was used in Flow cytometry/Cell sorting to study the VEGF-Jagged1-Notch pathway and the effects of T cells in pathogenic large vessel vasculitis.
Wed Jul 19 00:00:00 EDT 2017
Antigen-Presenting Human γδ T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin.
Journal of immunology (Baltimore, Md. : 1950)
Tyler CJ,McCarthy NE,Lindsay JO,Stagg AJ,Moser B,Eberl M
17-7179 was used in Flow cytometry/Cell sorting to study the role of γδ T cells in the regulation of IL-22 expression.
Mon May 01 00:00:00 EDT 2017
High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis.
Cosorich I,Dalla-Costa G,Sorini C,Ferrarese R,Messina MJ,Dolpady J,Radice E,Mariani A,Testoni PA,Canducci F,Comi G,Martinelli V,Falcone M
17-7179 was used in Flow cytometry/Cell sorting to assess the crucial role of the intestinal environment in promoting Th17 cell expansion in human multiple sclerosis patients.
Sat Jul 01 00:00:00 EDT 2017
Role of podoplanin in the high interleukin-17A secretion resulting from interactions between activated lymphocytes and psoriatic skin-derived mesenchymal cells.
Clinical and experimental immunology
Noack M,Ndongo-Thiam N,Miossec P
17-7179-42 was used in Flow cytometry/Cell sorting to study the interactions of skin-derived fibroblasts with peripheral blood mononuclear cells (PBMC) with a focus on the Th17 pathway and to identify a mechanism which leads to a high interleukin (IL)-17 secretion.
Sat Oct 01 00:00:00 EDT 2016
Reduced pro-inflammatory profile of γδT cells in pregnant patients with rheumatoid arthritis.
Arthritis research & therapy
Tham M,Schlör GR,Yerly D,Mueller C,Surbek D,Villiger PM,Förger F
17-7179 was used in Flow cytometry/Cell sorting to investigate whether pregnancy-related changes in disease activity were associated with changes in the proportion and function of γδT cells.
Fri Jan 22 00:00:00 EST 2016
Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vγ2Vδ2 T cells after Mycobacterium tuberculosis infection or vaccination.
European journal of immunology
Shen H,Wang Y,Chen CY,Frencher J,Huang D,Yang E,Ryan-Payseur B,Chen ZW
17-7179 was used in Flow cytometry/Cell sorting to examine the involvement of cytokines in the adaptive immune response to bacterial infection.
Sun Feb 01 00:00:00 EST 2015
Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients.
Mediators of inflammation
Bjerg Christensen A,Dige A,Vad-Nielsen J,Brinkmann CR,Bendix M,Østergaard L,Tolstrup M,Søgaard OS,Rasmussen TA,Randel Nyengaard J,Agnholt J,Denton PW
17-7179 was used in Flow cytometry/Cell sorting to investigate the effects of new therapeutic strategies for HIV treatment in the intestines.
Mon Sep 26 00:00:00 EDT 2016
The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjögren's Syndrome.
Journal of immunology research
Li L,He J,Zhu L,Yang Y,Jin Y,Jia R,Liu X,Liu Y,Sun X,Li Z
17-7179 was used in Flow cytometry/Cell sorting to assess the contribution of CD4+CD161+ T cell populations to the development of Sjögren's syndrome.
Tue May 24 00:00:00 EDT 2016
Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects.
Plé C,Fan Y,Ait Yahia S,Vorng H,Everaere L,Chenivesse C,Balsamelli J,Azzaoui I,de Nadai P,Wallaert B,Lazennec G,Tsicopoulos A
17-7179 was used in Flow cytometry/Cell sorting to investigate whether PAH affects production of IL-17 and IL-22 production in allergic asthma, showing they reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells.
Thu Mar 31 00:00:00 EDT 2016
Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.
Li H,Richert-Spuhler LE,Evans TI,Gillis J,Connole M,Estes JD,Keele BF,Klatt NR,Reeves RK
17-7179-42 was used in Flow cytometry/Cell sorting to demonstrate the first evidence for acute, systemic, and permanent loss of mucosal innate lymphoid cells during SIV infection associated with reduction of IL-17.
Mon Dec 01 00:00:00 EST 2014
Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.
Kongsbak M,von Essen MR,Boding L,Levring TB,Schjerling P,Lauritsen JP,Woetmann A,Ødum N,Bonefeld CM,Geisler C
17-7179 was used in Flow cytometry/Cell sorting to determine if and how 1,25(OH)2D3 by itself regulates vitamin D receptor (VDR) expression in human CD4+ T cells.
Thu Jun 04 00:00:00 EDT 2015
Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction.
Liu X,Gao N,Li M,Xu D,Hou Y,Wang Q,Zhang G,Sun Q,Zhang H,Zeng X
17-7179 was used in Flow cytometry/Cell sorting to investigate the role of Treg subsets in the immune imbalance in naive systemic sclerosis (SSc), showing that elevated levels of CD4(+)CD25(+)FoxP3(+) T cells contribute to the secretion of IL-17 and immunosuppression dysfunction.
Thu Jan 16 00:00:00 EST 2014
Peripherally circulating CD4⁺ FOXP3⁺ CXCR3⁺ T regulatory cells correlate with renal allograft function.
Scandinavian journal of immunology
Hoerning A,Köhler S,Jun C,Tebbe B,Fu J,Menke J,Wilde B,Dolff S,Feldkamp T,Briscoe DM,Kribben A,Hoyer PF,Witzke O
17-7179 was used in Flow cytometry/Cell sorting to investigate the relevance of trafficking receptors for Tregs after solid organ transplantation.
Sat Sep 01 00:00:00 EDT 2012
Tumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent.
Feyler S,Scott GB,Parrish C,Jarmin S,Evans P,Short M,McKinley K,Selby PJ,Cook G
17-7179 was used in Immunofluorescence to provide further evidence of direct tumour manipulation of the immune system to augment immune evasion and propagation of the malignant cell clone.
Mon Oct 29 00:00:00 EDT 2012
IL-21 regulates the differentiation of a human γδ T cell subset equipped with B cell helper activity.
Caccamo N,Todaro M,La Manna MP,Sireci G,Stassi G,Dieli F
17-7179 was used in Flow cytometry/Cell sorting to characterise a follicular B-helper T cell subset formed when Vγ9Vδ2 T lymphocytes are cocultured with phosphoantigen and IL-21.
Thu Jan 10 00:00:00 EST 2013
Differentiation, phenotype, and function of interleukin-17-producing human Vγ9Vδ2 T cells.
Caccamo N,La Mendola C,Orlando V,Meraviglia S,Todaro M,Stassi G,Sireci G,Fournié JJ,Dieli F
17-7179 was used in Flow cytometry/Cell sorting to describe a new subset of human IL-17(+) Vγ9Vδ2 T lymphocytes implicated in the inflammatory responses during bacterial infections.
Thu Jul 07 00:00:00 EDT 2011
Prostaglandin E2 and IL-23 plus IL-1β differentially regulate the Th1/Th17 immune response of human CD161(+) CD4(+) memory T cells.
Clinical and translational science
Barrie A,Khare A,Henkel M,Zhang Y,Barmada MM,Duerr R,Ray A
17-7179 was used in Flow cytometry/Cell sorting to suggest that Th17-mediated chronic inflammatory bowel disease depends on a threshold response of CD161(+) CD4(+) memory T cells to both PGE2 and IL-23 plus IL-1β.
Mon Aug 01 00:00:00 EDT 2011