|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human IL-18.|
|Storage buffer||PBS, pH 7.2, with 50% glycerol|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Elevated levels of IL-18 in plasma and skeletal muscle in chronic obstructive pulmonary disease.||Petersen AM,Penkowa M,Iversen M,Frydelund-Larsen L,Andersen JL,Mortensen J,Lange P,Pedersen BK||Lung (185:161)||2007|
Fiber type specific expression of TNF-alpha, IL-6 and IL-18 in human skeletal muscles.
AHC8181 was used in immunohistochemistry to report cytokine production by resting healthy human muscles
|Plomgaard P,Penkowa M,Pedersen BK||Exercise immunology review (11:53)||2006|