Product References
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-7021 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
TNIK signaling imprints CD8+ T cell memory formation early after priming.
Nature communications
Jaeger-Ruckstuhl CA,Hinterbrandner M,Höpner S,Correnti CE,Lüthi U,Friedli O,Freigang S,Al Sayed MF,Bührer ED,Amrein MA,Schürch CM,Radpour R,Riether C,Ochsenbein AF
14-7021-81 was used in Flow Cytometry to analyse the role of the TRAF2-/NCK-interacting kinase (TNIK), a signaling molecule downstream of the tumor necrosis factor superfamily receptors such as CD27, in the regulation of CD8+ T cell fate during acute infection with lymphocytic choriomeningitis virus.
Thu Apr 02 00:00:00 EDT 2020
Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model.
Vaccines
Reeder SM,Reuschel EL,Bah MA,Yun K,Tursi NJ,Kim KY,Chu J,Zaidi FI,Yilmaz I,Hart RJ,Perrin B,Xu Z,Humeau L,Weiner DB,Aly ASI
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in Flow Cytometry
Fri Jan 10 00:00:00 EST 2020
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Activation of CD8⁺ T Cell Responses after Melanoma Antigen Targeting to CD169⁺ Antigen Presenting Cells in Mice and Humans.
Cancers
van Dinther D,Lopez Venegas M,Veninga H,Olesek K,Hoogterp L,Revet M,Ambrosini M,Kalay H,Stöckl J,van Kooyk Y,den Haan JMM
14-7021 was used in Flow cytometry/Cell sorting to indicate that Ab-mediated antigen targeting to CD169 is a potential strategy for the induction of melanoma-specific T cell responses in mice and in humans.
Tue Feb 05 00:00:00 EST 2019
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
The Journal of experimental medicine
Yang J,Cornelissen F,Papazian N,Reijmers RM,Llorian M,Cupedo T,Coles M,Seddon B
14-7021 was used in Flow cytometry/Cell sorting to investigate whether continued IL-7 expression was required for the maintenance of fully developed, adult lymph nodes.
Mon Apr 02 00:00:00 EDT 2018
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection.
PloS one
Fontana MF,Baccarella A,Craft JF,Boyle MJ,McIntyre TI,Wood MD,Thorn KS,Anidi C,Bayat A,Chung MR,Hamburger R,Kim CY,Pearman E,Pham J,Tang JJ,Boon L,Kamya MR,Dorsey G,Feeney ME,Kim CC
14-7021 was used in Flow cytometry/Cell sorting to investigate aspects of the human immune response to asymptomatic persistent Plasmodium infection using a novel animal model.
Wed Aug 02 00:00:00 EDT 2017
Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells.
Cancer immunology research
Zahm CD,Colluru VT,McNeel DG
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.
EBioMedicine
Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-7021 was used in Flow cytometry/Cell sorting to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 EDT 2017
Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.
Nature communications
Park S,Lee S,Lee CG,Park GY,Hong H,Lee JS,Kim YM,Lee SB,Hwang D,Choi YS,Fryer JD,Im SH,Lee SW,Lee Y
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in ELISA
Wed Jul 12 00:00:00 EDT 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Group B Streptococcus Induces a Robust IFN-γ Response by CD4(+) T Cells in an In Vitro and In Vivo Model.
Journal of immunology research
Clarke D,Letendre C,Lecours MP,Lemire P,Galbas T,Thibodeau J,Segura M
14-7021 was used in Flow cytometry/Cell sorting to investigate the source of IFN-γ during group B Streptococcus serotype III infection, showing robust IFN-γ response by CD4(+) T cells.
Tue Nov 01 00:00:00 EDT 2016
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang Q,Gao X,Li C,Feliciano C,Wang D,Zhou D,Mei Y,Monteiro P,Anand M,Itohara S,Dong X,Fu Z,Feng G
14-7021 was used in Immunohistochemistry to study the neurobiological function of SORBS2 in the brain.
Wed Feb 17 00:00:00 EST 2016
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation.
Nature communications
Bulla R,Tripodo C,Rami D,Ling GS,Agostinis C,Guarnotta C,Zorzet S,Durigutto P,Botto M,Tedesco F
14702181 was used in flow cytometry to suggest that locally synthesized C1q promotes tumor growth
Mon Feb 01 00:00:00 EST 2016
Hair follicle dermal sheath derived cells improve islet allograft survival without systemic immunosuppression.
Journal of immunology research
Wang X,Hao J,Leung G,Breitkopf T,Wang E,Kwong N,Akhoundsadegh N,Warnock GL,Shapiro J,McElwee KJ
14-7021 was used in an ELISA assay to investigate a new treatment for autoimmune diabetes using naturally immune privileged, hair follicle derived, autologous cells.
Tue Jan 26 00:00:00 EST 2016
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.
The Journal of experimental medicine
Omilusik KD,Best JA,Yu B,Goossens S,Weidemann A,Nguyen JV,Seuntjens E,Stryjewska A,Zweier C,Roychoudhuri R,Gattinoni L,Bird LM,Higashi Y,Kondoh H,Huylebroeck D,Haigh J,Goldrath AW
14-7021-81 was used in Flow Cytometry to study the upregulation of ZEB2 by activated T cells, specifically in the KLRG1(hi) effector CD8(+) T cell subset.
Mon Nov 16 00:00:00 EST 2015
The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.
PLoS pathogens
Khan SH,Martin MD,Starbeck-Miller GR,Xue HH,Harty JT,Badovinac VP
14-7021 was used in Flow cytometry/Cell sorting to address whether the timing of stimulation of 1° memory CD8 T cells modulates sensitivity to IL-2 signaling, thereby affecting 2° expansion and 2° CD8 T cell differentiation.
Thu Oct 01 00:00:00 EDT 2015
An atlas of mouse CD4(+) T cell transcriptomes.
Biology direct
Stubbington MJ,Mahata B,Svensson V,Deonarine A,Nissen JK,Betz AG,Teichmann SA
14-7021 was used in Functional assays to show that hundreds of genes are regulated purely by alternative splicing to extend our knowledge of the role of post-transcriptional regulation in cell differentiation.
Fri Apr 03 00:00:00 EDT 2015
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife
Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG
14-7021 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.
Mon Oct 27 00:00:00 EDT 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-7021-81 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis.
mBio
Prados-Rosales R,Carreño LJ,Batista-Gonzalez A,Baena A,Venkataswamy MM,Xu J,Yu X,Wallstrom G,Magee DM,LaBaer J,Achkar JM,Jacobs WR,Chan J,Porcelli SA,Casadevall A
14-7021 was used in Flow cytometry/Cell sorting to compare the effects of immunisation with membrane vesicles to those of the standard Bacillus Calmette-Guerin vaccination.
Tue Sep 30 00:00:00 EDT 2014
Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis.
mBio
Prados-Rosales R,Carreño LJ,Batista-Gonzalez A,Baena A,Venkataswamy MM,Xu J,Yu X,Wallstrom G,Magee DM,LaBaer J,Achkar JM,Jacobs WR,Chan J,Porcelli SA,Casadevall A
14-7021 was used in Flow cytometry/Cell sorting to compare the effects of immunisation with membrane vesicles to those of the standard Bacillus Calmette-Guerin vaccination.
Tue Sep 30 00:00:00 EDT 2014
Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.
PLoS neglected tropical diseases
Roupie V,Pidot SJ,Einarsdottir T,Van Den Poel C,Jurion F,Stinear TP,Huygen K
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in ELISA
Mon Sep 08 00:00:00 EDT 2014
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Cancer research
Ho PC,Meeth KM,Tsui YC,Srivastava B,Bosenberg MW,Kaech SM
14-7021 was used in Flow cytometry/Cell sorting to investigate whether B-Raf(V600E) inhibitors promote tumor regression with the help of host immunity, showing that they rely on signaling by CD40L and IFNγ.
Sun Jun 15 00:00:00 EDT 2014
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-7021 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 EDT 2014
IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
PLoS pathogens
Villegas-Mendez A,de Souza JB,Lavelle SW,Gwyer Findlay E,Shaw TN,van Rooijen N,Saris CJ,Hunter CA,Riley EM,Couper KN
14-7021 was used in Flow cytometry/Cell sorting to investigate the molecular basis of IL-27 receptor/ WSX-1-mediated regulation of Th1 responses in vivo during malaria infection.
Fri Jan 10 00:00:00 EST 2014
Differentiation of antigen-specific T cells with limited functional capacity during Mycobacterium tuberculosis infection.
Infection and immunity
Jeong YH,Jeon BY,Gu SH,Cho SN,Shin SJ,Chang J,Ha SJ
14-7021 was used in Flow cytometry/Cell sorting to investigate the phenotype and function of different antigen-specific T cells during Mycobacterium tuberculosis infection.
Wed Jan 01 00:00:00 EST 2014
CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells.
Journal of virology
Manzke N,Akhmetzyanova I,Hasenkrug KJ,Trilling M,Zelinskyy G,Dittmer U
14-7021 was used in Flow cytometry/Cell sorting to investigate how both Tregs and CD8(+) T cells influence the cytotoxic activity of conventional CD4(+) T cells during an acute retroviral infection.
Sat Jun 01 00:00:00 EDT 2013
Identification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profiling.
PLoS pathogens
Hafalla JC,Bauza K,Friesen J,Gonzalez-Aseguinolaza G,Hill AV,Matuschewski K
14-7021 was used in Flow cytometry/Cell sorting to investigate antigenic epitopes in a murine malaria immunisation model.
Wed May 01 00:00:00 EDT 2013
Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection.
Journal of virology
Trujillo JA,Fleming EL,Perlman S
14-7021 was used in Flow cytometry/Cell sorting to examine the role of CCL2 during virus infection, showing that CCL2 expression in the CNS results in a dysregulated immune response after coronavirus infection.
Fri Mar 01 00:00:00 EST 2013
Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function.
Scientific reports
Chang RA,Miller SD,Longnecker R
14-7021 was used in an ELISpot assay to investigate the Epstein-Barr virus as a possible etiological agent involved in multiple sclerosis.
Mon Feb 25 00:00:00 EST 2013
Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.
Journal of immunology (Baltimore, Md. : 1950)
Kastenmuller W,Gasteiger G,Subramanian N,Sparwasser T,Busch DH,Belkaid Y,Drexler I,Germain RN
14-7021 was used in Flow cytometry/Cell sorting to show that Tregs act on the developing immune response early postinfection by reducing the extent of dendritic cell costimulatory molecule expression.
Thu Sep 15 00:00:00 EDT 2011
Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Rudolph M,Hebel K,Miyamura Y,Maverakis E,Brunner-Weinzierl MC
14-7021 was used in Flow cytometry/Cell sorting to investigate the role of CTLA-4 on memory formation of adaptive immune responses using anti-CTLA-4 mAb treatment in mice.
Sun May 15 00:00:00 EDT 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
14-7021 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 EST 2011
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
14-7021 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 EST 2010
Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.
Journal of immunology (Baltimore, Md. : 1950)
Gibbert K,Dietze KK,Zelinskyy G,Lang KS,Barchet W,Kirschning CJ,Dittmer U
14-7021 was used in Flow cytometry/Cell sorting to investigate the mode of action of poly(I:C) in antiretroviral immunotherapy.
Mon Nov 15 00:00:00 EST 2010
Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.
PLoS pathogens
Wilson DC,Grotenbreg GM,Liu K,Zhao Y,Frickel EM,Gubbels MJ,Ploegh HL,Yap GS
14-7021 was used in Flow cytometry/Cell sorting to identify a novel H-2K(b)-restricted CTL population specific for the Toxoplasma antigen tgd057.
Fri Mar 19 00:00:00 EDT 2010
In vivo expansion of activated naive CD8+ T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Tomala J,Chmelova H,Mrkvan T,Rihova B,Kovar M
14-7021 was used in Flow cytometry/Cell sorting to investigate the potential for replacement of IL-2 by IL-2 immunocomplexes for cancer therapy.
Thu Oct 15 00:00:00 EDT 2009
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens
Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL
14-7021 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.
Thu Oct 01 00:00:00 EDT 2009
Tentative T cells: memory cells are quick to respond, but slow to divide.
PLoS pathogens
Whitmire JK,Eam B,Whitton JL
14-7021 was used in Flow cytometry/Cell sorting to evaluate whether memory T cells initiate cell division much more rapidly than their naïve counterparts upon encountering the relevant pathogen.
Fri Apr 11 00:00:00 EDT 2008
Modulation of pulmonary dendritic cell function during mycobacterial infection.
Infection and immunity
Anis MM,Fulton SA,Reba SM,Liu Y,Harding CV,Boom WH
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in ELISA
Fri Feb 01 00:00:00 EST 2008
Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.
Diabetes
Tritt M,Sgouroudis E,d'Hennezel E,Albanese A,Piccirillo CA
14-7021 was used in Flow cytometry/Cell sorting to study how Foxp3-expressing nT(reg) cells in NOD mice regulate diabetogenesis, but temporal alterations in nT(reg) cell function promote immune dysregulation and the onset of spontaneous autoimmunity.
Tue Jan 01 00:00:00 EST 2008
Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.
Infection and immunity
Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH
Published figure using IL-2 monoclonal antibody (Product # 14-7021-81) in ELISA
Tue May 01 00:00:00 EDT 2007
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Immunity
Marie JC,Liggitt D,Rudensky AY
14-7021 was used in Immunocytochemistry to demonstrate that TGF-beta signalling in T cells is crucial to restrain fatal autoimmune processes.
Fri Sep 01 00:00:00 EDT 2006
actin or actin-binding cytoskeletal protein
