Product References
Nanobody-derived bispecific CAR-T cell therapy enhances the anti-tumor efficacy of T cell lymphoma treatment.
Molecular therapy oncolytics
Xia B,Lin K,Wang X,Chen F,Zhou M,Li Y,Lin Y,Qiao Y,Li R,Zhang W,He X,Zou F,Li L,Lu L,Chen C,Li W,Zhang H,Liu B
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Thu Sep 21 00:00:00 EDT 2023
Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents.
Nature communications
Koerber N,Priller A,Yazici S,Bauer T,Cheng CC,Mijočević H,Wintersteller H,Jeske S,Vogel E,Feuerherd M,Tinnefeld K,Winter C,Ruland J,Gerhard M,Haller B,Christa C,Zelger O,Roggendorf H,Halle M,Erber J,Lingor P,Keppler O,Zehn D,Protzer U,Knolle PA
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Mon Jan 10 00:00:00 EST 2022
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs.
Nature cell biology
Truong DJ,Armbrust N,Geilenkeuser J,Lederer EM,Santl TH,Beyer M,Ittermann S,Steinmaßl E,Dyka M,Raffl G,Phlairaharn T,Greisle T,Živanić M,Grosch M,Drukker M,Westmeyer GG
14-7029-81 was used in Enzyme-linked immunosorbent assay to develop the intron-encoded scarless programmable extranuclear cistronic transcript (INSPECT) as a minimally invasive transcriptional reporter embedded within an intron of a gene of interest.
Tue Nov 01 00:00:00 EDT 2022
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Immunity
Schwabenland M,Salié H,Tanevski J,Killmer S,Lago MS,Schlaak AE,Mayer L,Matschke J,Püschel K,Fitzek A,Ondruschka B,Mei HE,Boettler T,Neumann-Haefelin C,Hofmann M,Breithaupt A,Genc N,Stadelmann C,Saez-Rodriguez J,Bronsert P,Knobeloch KP,Blank T,Thimme R,Glatzel M,Prinz M,Bengsch B
14-7029-81 was used in Mass cytometry to identify profound neuroinflammation with activation of innate and adaptive immune cells as correlates of COVID-19 neuropathology, with implications for potential therapeutic strategies.
Tue Jul 13 00:00:00 EDT 2021
Decreased Frequencies of Gamma/Delta T Cells Expressing Th1/Th17 Cytokine, Cytotoxic, and Immune Markers in Latent Tuberculosis-Diabetes/Pre-Diabetes Comorbidity.
Frontiers in cellular and infection microbiology
Kathamuthu GR,Kumar NP,Moideen K,Menon PA,Babu S
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Thu Nov 25 00:00:00 EST 2021
Platelets stimulate programmed death-ligand 1 expression by cancer cells: Inhibition by anti-platelet drugs.
Journal of thrombosis and haemostasis : JTH
Asgari A,Lesyk G,Poitras E,Govindasamy N,Terry K,To R,Back V,Rudzinski JK,Lewis JD,Jurasz P
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells.
Cell reports
Wu B,Woo JS,Vila P,Jew M,Leung J,Sun Z,Srikanth S,Gwack Y
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Tue Aug 24 00:00:00 EDT 2021
Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV.
Nature communications
Alrubayyi A,Gea-Mallorquí E,Touizer E,Hameiri-Bowen D,Kopycinski J,Charlton B,Fisher-Pearson N,Muir L,Rosa A,Roustan C,Earl C,Cherepanov P,Pellegrino P,Waters L,Burns F,Kinloch S,Dong T,Dorrell L,Rowland-Jones S,McCoy LE,Peppa D
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Tue Oct 05 00:00:00 EDT 2021
Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory-Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand.
Cancer research communications
Ando M,Kondo T,Tomisato W,Ito M,Shichino S,Srirat T,Mise-Omata S,Nakagawara K,Yoshimura A
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity.
Molecular therapy. Methods & clinical development
Preece R,Pavesi A,Gkazi SA,Stegmann KA,Georgiadis C,Tan ZM,Aw JYJ,Maini MK,Bertoletti A,Qasim W
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Fri Dec 11 00:00:00 EST 2020
A novel format for recombinant antibody-interleukin-2 fusion proteins exhibits superior tumor-targeting properties in vivo.
Oncotarget
Ongaro T,Gouyou B,Stringhini M,Corbellari R,Neri D,Villa A
14-7029-85 was used in Immunohistochemistry (Frozen) to study the in vivo tumor-homing and anti-cancer activity of antibody-interleukin 2 fusion proteins.
Tue Oct 13 00:00:00 EDT 2020
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma.
Cancer immunology research
Josefsson SE,Beiske K,Blaker YN,Førsund MS,Holte H,Østenstad B,Kimby E,Köksal H,Wälchli S,Bai B,Smeland EB,Levy R,Kolstad A,Huse K,Myklebust JH
14-7029 was used in Flow cytometry/Cell sorting to show that TIGIT and PD-1 mark dysfunctional T cells and suggest that TIGIT and PD-1 coblockade should be further explored to elicit potent antitumor responses in patients with NHL.
Fri Mar 01 00:00:00 EST 2019
Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice.
Molecular cancer therapeutics
Ziffels B,Stringhini M,Probst P,Fugmann T,Sturm T,Neri D
14-7029-81 was used in Immunohistochemistry-immunofluorescence to describe the design, production, and characterization of four novel antibody-cytokine fusion proteins directed against human carbonic anhydrase IX, a highly validated marker of hypoxia that is overexpressed in clear cell renal cell carcinoma and other malignancies.
Sun Sep 01 00:00:00 EDT 2019
A Novel Fully-Human Potency-Matched Dual Cytokine-Antibody Fusion Protein Targets Carbonic Anhydrase IX in Renal Cell Carcinomas.
Frontiers in oncology
De Luca R,Gouyou B,Ongaro T,Villa A,Ziffels B,Sannino A,Buttinoni G,Galeazzi S,Mazzacuva M,Neri D
14-7029-85 was used in Immunohistochemistry (Frozen), Flow Cytometry to report the cloning, expression and characterization of IL2-XE114-TNFmut, a dual-cytokine biopharmaceutical featuring the sequential fusion of interleukin-2 (IL2) with the XE114 antibody in scFv format and a tumor necrosis factor mutant (TNFmut).
Thu Oct 01 00:00:00 EDT 2020
A Novel Fully-Human Potency-Matched Dual Cytokine-Antibody Fusion Protein Targets Carbonic Anhydrase IX in Renal Cell Carcinomas.
Frontiers in oncology
De Luca R,Gouyou B,Ongaro T,Villa A,Ziffels B,Sannino A,Buttinoni G,Galeazzi S,Mazzacuva M,Neri D
14-7029-85 was used in Immunohistochemistry (Frozen), Flow Cytometry to report the cloning, expression and characterization of IL2-XE114-TNFmut, a dual-cytokine biopharmaceutical featuring the sequential fusion of interleukin-2 (IL2) with the XE114 antibody in scFv format and a tumor necrosis factor mutant (TNFmut).
Thu Oct 01 00:00:00 EDT 2020
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
The Journal of experimental medicine
Carpier JM,Zucchetti AE,Bataille L,Dogniaux S,Shafaq-Zadah M,Bardin S,Lucchino M,Maurin M,Joannas LD,Magalhaes JG,Johannes L,Galli T,Goud B,Hivroz C
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Mon Apr 02 00:00:00 EDT 2018
A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies.
Protein engineering, design & selection : PEDS
De Luca R,Kachel P,Kropivsek K,Snijder B,Manz MG,Neri D
Published figure using IL-2 monoclonal antibody (Product # 14-7029-81) in Flow Cytometry
Tue May 01 00:00:00 EDT 2018
Prostate Cancer Cells Express More Androgen Receptor (AR) Following Androgen Deprivation, Improving Recognition by AR-Specific T Cells.
Cancer immunology research
Olson BM,Gamat M,Seliski J,Sawicki T,Jeffery J,Ellis L,Drake CG,Weichert J,McNeel DG
14-7029 was used in Flow cytometry/Cell sorting to suggest that ADT combined with AR-directed immunotherapy targets a major mechanism of resistance, overexpression of the AR.
Fri Dec 01 00:00:00 EST 2017
Optimization of mass cytometry sample cryopreservation after staining.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Sumatoh HR,Teng KW,Cheng Y,Newell EW
14702981 was used in flow cytometry to demonstrate that freezing already-stained samples suspended in 10% DMSO in FBS is practical and efficient way to preserve already-stained samples for mass cytometry assessment
Sun Jan 01 00:00:00 EST 2017
Effects of the levonorgestrel-releasing intrauterine device on the immune microenvironment of the human cervix and endometrium.
American journal of reproductive immunology (New York, N.Y. : 1989)
Shanmugasundaram U,Hilton JF,Critchfield JW,Greenblatt RM,Giudice LC,Averbach S,Seidman D,Shacklett BL,Smith-McCune K
14-7029 was used in Flow cytometry/Cell sorting to study the impact of the levonorgestrel-releasing intrauterine device on immune parameters of the upper female reproductive tract.
Mon Aug 01 00:00:00 EDT 2016
Loss of immune tolerance to IL-2 in type 1 diabetes.
Nature communications
Pérol L,Lindner JM,Caudana P,Nunez NG,Baeyens A,Valle A,Sedlik C,Loirat D,Boyer O,Créange A,Cohen JL,Rogner UC,Yamanouchi J,Marchant M,Leber XC,Scharenberg M,Gagnerault MC,Mallone R,Battaglia M,Santamaria P,Hartemann A,Traggiai E,Piaggio E
14-7029 was used in an ELISA assay to study the role of the loss of immune tolerance to IL-2 in type 1 diabetes.
Thu Oct 06 00:00:00 EDT 2016
PD-1 marks dysfunctional regulatory T cells in malignant gliomas.
JCI insight
Lowther DE,Goods BA,Lucca LE,Lerner BA,Raddassi K,van Dijk D,Hernandez AL,Duan X,Gunel M,Coric V,Krishnaswamy S,Love JC,Hafler DA
14-7029 was used in Flow cytometry/Cell sorting to study how high PD-1 expression on human Tregs identifies dysfunctional, exhausted Tregs secreting IFN-γ that exist in healthy individuals and are enriched in tumor infiltrates.
Thu Apr 21 00:00:00 EDT 2016
Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency.
Arthritis & rheumatology (Hoboken, N.J.)
Van Eyck L,De Somer L,Pombal D,Bornschein S,Frans G,Humblet-Baron S,Moens L,de Zegher F,Bossuyt X,Wouters C,Liston A
14-7029 was used in Flow cytometry/Cell sorting to determine the underlying genetic defect responsible for severe early onset and refractory systemic lupus erythematosus.
Mon Jun 01 00:00:00 EDT 2015
Fiber composite slices for multiplexed immunoassays.
Biomicrofluidics
Kim J,Bae S,Song S,Chung K,Kwon S
14-7029 was used in Immuno-assay to describe a new type of low-cost fabrication method for a scalable immunoassay platform based on cotton threads.
Wed Jul 01 00:00:00 EDT 2015
A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
Journal of virology
Van Rompay KK,Hunter Z,Jayashankar K,Peabody J,Montefiori D,LaBranche CC,Keele BF,Jensen K,Abel K,Chackerian B
14-7029 was used in Flow cytometry/Cell sorting to investigate whether prophylactic immunisation of rhesus macaques with a vaccine against CCR5 could prevent or suppress SIV.
Sat Feb 01 00:00:00 EST 2014
Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features.
Journal of immunology (Baltimore, Md. : 1950)
Arlehamn CL,Seumois G,Gerasimova A,Huang C,Fu Z,Yue X,Sette A,Vijayanand P,Peters B
14702981 was used in flow cytometry to investigate the impact of CCR6(+)CXCR3(+)CCR4(-) cells in latent tuberculosis infection
Mon Sep 15 00:00:00 EDT 2014
CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques.
AIDS research and human retroviruses
Lin PL,Rutledge T,Green AM,Bigbee M,Fuhrman C,Klein E,Flynn JL
14-7029 was used in Flow cytometry/Cell sorting to study initial CD4 T cell protection against acute M.tuberculosis infection and reactivation upon latent infection.
Sat Dec 01 00:00:00 EST 2012
CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques.
AIDS research and human retroviruses
Lin PL,Rutledge T,Green AM,Bigbee M,Fuhrman C,Klein E,Flynn JL
14-7029 was used in Flow cytometry/Cell sorting to study initial CD4 T cell protection against acute M.tuberculosis infection and reactivation upon latent infection.
Sat Dec 01 00:00:00 EST 2012