|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide of Human IL22 Receptor N terminal amino acids 42-70 [DSGPEGTPDTVYSIEYKTYGERDWVAKK]|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M potassium phosphate with 0.14M NaCl|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:300|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-21361 detects IL-22 Receptor in Human samples.
PA1-21361 has been successfully used in ELISA and Immunohistochemistry (paraffin) procedures.
PA1-21361 immunogen corresponds to Synthetic peptide of Human IL22 Receptor N terminal amino acids 42-70 [DSGPEGTPDTVYSIEYKTYGERDWVAKK].
The receptor for IL22 (also termed CRF29 and IL TIFR1 chain) is a new member of the class II cytokine receptor family. IL22 Receptor forms a complex with IL10 Receptor beta chain and mediates IL22 signaling. IL22 and its receptor activate the JAK/STAT signaling pathway. IL22 Receptor is expressed in normal liver and kidney and their cell lines HepG2 and TK10. A soluble form of IL22 Receptor, also termed IL22 binding protein (IL22BP) and IL22 receptor alpha 2 (IL22 RA2), was identified very recently. IL22BP prevents binding of IL22 to the functional cell surface IL22 Receptor complex and neutralizes IL22 activity. LPS induces IL22 expression, which indicates the role of IL22 in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.