The protein encoded by IL-27 is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
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Protein Aliases: IL 27; IL 27 A; IL 27 subunit alpha; IL 27A; IL-27 p28 subunit; IL-27 subunit alpha; IL-27-A; IL27; IL27 A; IL27-A; IL27A; IL27p28; IL30; interleukin 27; Interleukin 27 subunit alpha; interleukin 30; Interleukin-27 subunit alpha; Interleukin-30; p28
Gene Aliases: IL-27; IL-27A; IL27; IL27A; IL27p28; IL30; p28
UniProt ID: (Human) Q8NEV9
Entrez Gene ID: (Human) 246778