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Invitrogen
IL-29 Recombinant Rabbit Monoclonal Antibody (3H21L13)
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FIGURE: 1 / 7
IL-29 Antibody (704932) in ICC/IF
Immunofluorescence analysis of IL-29 was performed using IL-29 Recombinant Rabbit Monoclonal Antibody (3H21L13) (Product # 704932) on 70-80% confluent SW480 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton X-100 for 15 minutes and blocked with 2% BSA for 1 hour at room temperature. The cells were stained with IL-29 Recombinant Rabbit Monoclonal Antibody (3H21L13) (Product # 704932, 1:200) in 0.1% BSA, incubated at 4 degree Celsius overnight, followed by labelling with Donkey anti-Rabbit Ig... View More
Product Details
704932
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
3H21L13
Immunogen
Peptides corresponding to human IL-29 [aa21-aa34] and [aa182-aa200]
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Target Information
IFN-lambdas constitute a novel family of interferons that mediate the induction of anti-viral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known as IL-29, IL-28A, and IL-28B, respectively. Similar to type I IFNs, IFN-lambdas activate an intracellular signaling to promote gene expression. IFN-lambdas mediate their anti-viral protection through a class II cytokine receptor complex composed of two essential receptor proteins, CRF2-12/IFN-lambdaR1, which is unique to IFN-lambdas, and CFR2-4/IL-10R2, which is shared with IL-10, IL-22, and IL-26 receptors. The IFN-lambdas, IL-28 and IL-29, have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. DCs that differentiate in response to IFN-lambdas express high levels of class I and II MHC gene products, but low levels of costimulatory molecules. Moreover, these cells can specifically induce IL-2-dependent proliferation of CD4+CD25+FOXP3+ T cells with contact-dependent suppressive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytokine Zcyto21; FNL1; IFN lambda1; IFN-lambda-1; IL-29; ILN; Interferon lambda-1; Interferon lambda1; interferon, lambda 1; interferon-lambda-1; Interleukin; interleukin 29 (interferon, lambda 1); Interleukin-29
Gene Aliases: IFNL1; IL-29; IL29; ZCYTO21
UniProt ID: (Human) Q8IU54
Entrez Gene ID: (Human) 282618
negative regulation of type 2 immune response
JAK-STAT cascade
negative regulation of cell proliferation
negative regulation of interleukin-13 production
negative regulation of interleukin-5 production
positive regulation of interferon-gamma production
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of memory T cell differentiation
innate immune response
positive regulation of MHC class I biosynthetic process
negative regulation of T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of JAK-STAT cascade
positive regulation of immune response
defense response to virus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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