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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:150-1:300|
|Immunohistochemistry (Frozen) (IHC (F))||1:50-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
MA1-91221 detects CD25 from human samples.
MA1-91221 has been successfully used in flow cytometry and immunohistochemistry (frozen tissue) applications. Positive control of tonsil, thymus, and spleen suggested.
The MA1-91221 immunogen is Human leucocytes.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
IL-23/IL-17 immunity as a hallmark of Crohn's disease.
MA1-91221 was used in immunohistochemistry to study IL-23/IL-17 immunity as a hallmark of Crohn's disease
|H?ltt? V,Klemetti P,Sipponen T,Westerholm-Ormio M,Kociubinski G,Salo H,R?s?nen L,Kolho KL,F?rkkil? M,Savilahti E,Vaarala O||Inflammatory bowel diseases (14:1175)||2008|
IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2 RA antibody; IL2-RA; Il2ra antibody; Interleukin 2 receptor alpha chain antibody; interleukin-2 receptor subunit alpha; p55; TAC antigen; TAC antigen antibody
CD25; IDDM10; IL2R; RP11-536K7.1; TCGFR
Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Intracellular signaling cascade JAK-STAT cascade Cell communication Ligand-mediated signaling Immunity and defense T-cell mediated immunity