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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG1|
|Immunogen||B6.1 CTL Cell line|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.1 ug/10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17814 targets CD25/IL-2R alpha chain in FACS and IHC (F) applications and shows reactivity with Mouse samples.
The MA5-17814 immunogen is b6.1 CTL Cell line.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates.
MA5-17814 was used in flow cytometry to investigate the mucosal inflammatory T-cell immunity induced by Yersinia enterocolitica infection
|Echeverry A,Saijo S,Schesser K,Adkins B||Infection and immunity (78:3595)||2010|
|Not Applicable||Not Cited||
In vitro suppression of CD8+ T cell function by Friend virus-induced regulatory T cells.
MA5-17814 was used to investigate the mechanism involved in the suppression of CD8+ T cells by Friend retrovirus-induced T regulatory cells
|Robertson SJ,Messer RJ,Carmody AB,Hasenkrug KJ||Journal of immunology (Baltimore, Md. : 1950) (176:3342)||2006|
Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation.
MA5-17814 was used in flow cytometry to determine the signaling duration requirements for priming and clonal expansion of naive cytotoxic T lymphocytes.
|van Stipdonk MJ,Lemmens EE,Schoenberger SP||Nature immunology (2:423)||2001|
Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells.
MA5-17814 was used in flow cytometry to assess the effects of folate analogues on superantigen-reactive peripheral T cells in vivo.
|Izeradjene K,Revillard JP,Genestier L||International immunology (13:85)||2001|
|Not Applicable||Not Cited||
Dectin-1 is required for beta-glucan recognition and control of fungal infection.
MA5-17814 was used in flow cytometry to report that dectin-1 deficiency renders mice susceptible to infection with Candida albicans
|Taylor PR,Tsoni SV,Willment JA,Dennehy KM,Rosas M,Findon H,Haynes K,Steele C,Botto M,Gordon S,Brown GD||Nature immunology (8:31)||2007|
CD25; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2 RA antibody; IL2-RA; Il2ra antibody; Interleukin 2 receptor alpha chain antibody; Interleukin-2 receptor subunit alpha; p55; p55 chain; TAC antigen antibody
CD25; Il2r; Il2ra; Ly-43