Immunogen sequence: AFGISGVQKY TRALHDSSIT GISPITEYLA SLSTYNDQSI TFALEDESYE IYVEDLKKDE KKDKVLLSYY ESQHPSNESG DGVDGKMLMV TLSPTKDFWL HANNKEHSVE LHKCEKPLPD QAFFVLHNMH SNCVSFECKT DPGVFIGVKD NHLALIKVDS SENLCTENIL FKLSET; Positive Samples: NCI-H460, SGC-7901, MCF7, Rat kidney; Cellular Location: Chromosome, Cytoplasmic vesicle, Nucleus, secretory vesicle
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.
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Protein Aliases: DVS27-related protein; IL-1F11; IL-33; Interleukin-1 family member 11; Interleukin-33; Interleukin-33 (109-270); Interleukin-33 (95-270); Interleukin-33 (99-270); NF-HEV; nuclear factor for high endothelial venules; Nuclear factor from high endothelial venules
Gene Aliases: C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV; NFHEV; RGD1311155