|Tested species reactivity||Rat|
|Published species reactivity||Rat|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Purified recombinant rat IL-6.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Interleukin 6 is a cytokine secreted by T cells and macrophages, has shown to exhibit activity in response to tissue damage and infection. They have also been found to be involved in various other activities like development of blood, cancer, embryonic development, and regulation of the immune system. IL6 is included in a family of other cytokines which include ciliary neurotrophic factor, cardiotrophin-1, leukemia inhibitory factor and interleukin 11. IL-6 can bring about differentiation through a receptor system which requires a specific receptor and a signaling subunit, gp130.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Trolox mitigates fibrosis in a bile duct ligation model.
ARC0962 was used in western blot to assess the role of trolox in chronic bile duct ligation.
|Galicia-Moreno M,Favari L,Muriel P||Fundamental and clinical pharmacology (27:308)||2013|
Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model.
ARC0962 was used in western blot to evaluate the ability of N-acetylcysteine to prevent the damage induced by bile duct ligation in rats.
|Galicia-Moreno M,Favari L,Muriel P||European journal of gastroenterology and hepatology (24:179)||2012|
|Rat||Not Cited||A novel fluorinated stilbene exerts hepatoprotective properties in CCl(4)-induced acute liver damage.||Rivera H,Morales-Ríos MS,Bautista W,Shibayama M,Tsutsumi V,Muriel P,Pérez-Álvarez V||Canadian journal of physiology and pharmacology (89:759)||2011|
Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation.
ARC0962 was used in blocking assay to investigate the role of IL-6 in axon regeneration.
|Leibinger M,Müller A,Gobrecht P,Diekmann H,Andreadaki A,Fischer D||Cell death and disease (4:null)||2013|