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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG1|
|Immunogen||Recombinant mouse IL-6|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MM600C targets IL-6 in ELISA, IHC(P), IP, Neu, and WB applications and shows reactivity with mouse samples.
The MM600C immunogen is recombinant mouse IL-6.
MM600C detects IL-6 which has a predicted molecular weight of approximately 22 kDa.
This antibody is produced by injecting Rat IgG secreting hybridoma cells into the peritoneum of mice. The resulting ascites is collected from the mice and the antibody is purified.
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
PmpG303-311, a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice.
MM600C was used in ELISA to study a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice
|Johnson RM,Yu H,Kerr MS,Slaven JE,Karunakaran KP,Brunham RC||Infection and immunity (80:2204)||2012|
Real-time imaging of mechanically injured femoral artery in mice reveals a biphasic pattern of leukocyte accumulation.
MM600C was used in ELISA to investigate the leukocyte accumulation process during artery injury
|Osaka M,Hagita S,Haraguchi M,Kajimura M,Suematsu M,Yoshida M||American journal of physiology. Heart and circulatory physiology (292:H1876)||2007|
Pattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines.
MM600C was used in ELISA to investigate the role of TLRs during the responses of epithelial cells induced by C. trachomatis infection
|Derbigny WA,Kerr MS,Johnson RM||Journal of immunology (Baltimore, Md. : 1950) (175:6065)||2005|
Toll-like receptor 2- and 6-mediated stimulation by macrophage-activating lipopeptide 2 induces lipopolysaccharide (LPS) cross tolerance in mice, which results in protection from tumor necrosis factor alpha but in only partial protection from lethal LPS doses.
MM600C was used in ELISA to study the effect of macrophage-activating lipopeptide 2 on toll-like receptor 2- and 6-mediated stimulation
|Deiters U,Gumenscheimer M,Galanos C,Mühlradt PF||Infection and immunity (71:4456)||2003|
Effect of MALP-2, a lipopeptide from Mycoplasma fermentans, on bone resorption in vitro.
MM600C was used in ELISA to study the effect of Mycoplasma fermentans lipopeptide MALP-2 on bone resorption
|Piec G,Mirkovitch J,Palacio S,Mühlradt PF,Felix R||Infection and immunity (67:6281)||1999|
Mycoplasmal lipopeptide MALP-2 induces the chemoattractant proteins macrophage inflammatory protein 1alpha (MIP-1alpha), monocyte chemoattractant protein 1, and MIP-2 and promotes leukocyte infiltration in mice.
MM600C was used in ELISA to study the effect of mycoplasmal lipopeptide MALP-2 on the expression of chemoattractant proteins and on leukocyte infiltration
|Deiters U,Mühlradt PF||Infection and immunity (67:3390)||1999|
Acute phase response induction by cancer treatment with photodynamic therapy.
MM600C was used in blocking or activating experiment to study the induction of the acute phase response by photodynamic therapy in cancer
|Korbelik M,Cecic I,Merchant S,Sun J||International journal of cancer (122:1411)||2008|
Mechanisms of strain-dependent development of mast cells from mouse splenocytes.
MM600C was used in blocking or activating experiment to study the mechanisms underlying the strain-dependent development of mast cells from mouse splenocytes
|Hu ZQ,Zhao WH,Shimamura T||Immunology and cell biology (84:184)||2006|
Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors.
MM600C was used in blocking/activating experiment to investigate the effect of photodynamic therapy on peripheral blood neutrophilia
|Cecic I,Korbelik M||Cancer letters (183:43)||2002|
B-cell hybridoma growth factor; interleukin HP-1; interleukin-6