Immunogen sequence: VESVPGYPRR LRASWTYPAS WPCQPHFLLK FRLQYRPAQH PAWSTVEPAG LEEVITDAVA GLPHAVRVSA RDFLDAGTWS TWSPEAWGTP STGTIPKEIP AWGQLHTQPE VEPQVDSPAP PRPSLQPHPR L
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 80%.
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012].
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Protein Aliases: AI314697; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11RA; IL11RA; Il11ra2; interleukin 11 receptor, alpha; interleukin-11 receptor alpha chain; Interleukin-11 receptor subunit alpha
Gene Aliases: CRSDA; IL11RA
UniProt ID: (Human) Q14626
Entrez Gene ID: (Human) 3590