|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 177-206 amino acids from the central region of human IL1A|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunocytochemistry (ICC)||See 1 publications below|
IL1A is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The epithelial danger signal IL-1¿ is a potent activator of fibroblasts and reactivator of intestinal inflammation.
PA5-25921 was used in immunocytochemistry and immunohistochemistry - paraffin section to investigate the effects of cell death and its products on intestinal epithelial cells with a focus on inflammatory bowel disease
|Scarpa M,Kessler S,Sadler T,West G,Homer C,McDonald C,de la Motte C,Fiocchi C,Stylianou E||The American journal of pathology (185:1624)||2015|