Sequence of this protein is as follows: LNQGECSSPD IQNSVEEETT MLLENDSPSE TIPEQTLLPD EFVSCLGIVN EELPSINTYF PQNILESHFN RISLLE
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
Protein Aliases: IBD17; IL 23R; IL-23 receptor; Interleukin-23 receptor
Gene Aliases: IL23R
UniProt ID: (Human) Q5VWK5
Entrez Gene ID: (Human) 149233
Molecular Function: transmembrane signal receptor