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OriGene
IL23R Monoclonal Antibody (OTI5C4), TrueMAB™
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FIGURE: 1 / 1
IL23R Antibody (CF807388) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL23R (RC211477, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-IL23R. Positive lysates LY403404 (100 µg) and LC403404 (20 µg) can be purchased separately from OriGene.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CF807388
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI5C4
Immunogen
Human recombinant protein fragment corresponding to amino acids 57-355 of human IL23R produced in E.coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hemopoietic cytokine receptor; IBD17; IL 23R; IL-23 receptor; IL-23R endodomain protein; IL-23R3-F3; IL-23R soluble receptor; IL-23R2-F1; IL-23R soluble receptor; IL-23R3-F1; IL-23R soluble receptor; IL-23R4; IL-23R truncated endodomain protein; IL-23R2-F2; IL23RL1-THE1A; type I cytokine receptor; IL-23R1
Gene Aliases: PSORS7
UniProt ID: (Human) Q5VWK5
Entrez Gene ID: (Human) 149233
positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
positive regulation of T-helper 1 type immune response
immune response
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
response to lipopolysaccharide
negative regulation of interleukin-10 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
response to interferon-gamma
interleukin-23-mediated signaling pathway
prolactin signaling pathway
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of memory T cell differentiation
positive regulation of osteoclast differentiation
positive regulation of JAK-STAT cascade
defense response to Gram-negative bacterium
positive regulation of NK T cell activation
positive regulation of NK T cell proliferation
receptor signaling pathway via STAT
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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