|Immunohistochemistry (IHC)||10 µg/ml|
|Western Blot (WB)||1-2 ug/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to amino acids near the center of human ILPIP.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is human brain tissue lysate.
PA5-20035 can be used with blocking peptide PEP-0154.
ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1-b converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; CALS-21; ILP-interacting protein; ILP-interacting protein homolog; ILP-interacting protein ILPIPA; polyploidy associated protein kinase; polyploidy associated protein kinase PAPK-A; Polyploidy-associated protein kinase; PRO1038, ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK; Pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STRAD beta
Gene Aliases: AA792893; ALS2CR2; B830008M19; CALS-21; D1Ucla2; ILPIP; ILPIPA; PAPK; PRO1038; RGD1559449; STRADB; Syradb
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