Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 289 and 568 of Human IMP3|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
PA5-30398 targets IMP3 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30398 immunogen is recombinant fragment corresponding to a region within amino acids 289 and 568 of Human IMP3.
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Diagnostic value of IMP3 and mesothelin in differentiating pancreatic ductal adenocarcinoma from chronic pancreatitis.
PA5-30398 was used in immunohistochemistry - paraffin section to characterize the diagnostic value of mesothelin and IMP3 in differentiatiating pancreatic ductal adenocarcinoma from chronic pancreatitis
|Ibrahim DA,Abouhashem NS||Pathology, research and practice (212:288)||2016|
BRMS2; cancer/testis antigen 98; CT98; IGF II mRNA binding protein 3; IMP3; IMP3, U3 small nucleolar ribonucleoprotein, homolog; insulin-l; KH domain containing protein overexpressed in cancer; KOC1; U3 small nucleolar ribonucleoprotein protein IMP3; U3 snoRNP protein 3 homolog; U3 snoRNP protein IMP3; VICKZ3
BRMS2; C15orf12; IMP3; MRPS4