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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Recombinant Monoclonal |
Type |
Antibody |
Clone |
ARC1479 |
Immunogen |
A synthesized peptide derived from human IMPDH2 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.517 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2849680 |
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMP oxireductase 2; IMPD 2; IMPD 2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPDH 2; IMPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPDH II; IMPDH-II; IMPDH2; inosine 5' phosphate dehydrogenase 2; inosine 5'-phosphate dehydrogenase 2; inosine 5-monophosphate dehydrogenase 2; inosine monophosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; Inosine-5'-monophosphate dehydrogenase 2; inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}
Gene Aliases: IMPD 2; IMPD2; IMPDH 2; IMPDH-II; IMPDH2
UniProt ID: (Human) P12268
Entrez Gene ID: (Human) 3615, (Rat) 301005
Molecular Function:
dehydrogenase
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