MA5-15315 targets INHA (Inhibin alpha) in IF and IHC applications and shows reactivity with Human samples.
The MA5-15315 immunogen is purified recombinant fragment of human INHA expressed in E. Coli.
MA5-15315 detects INHA (Inhibin alpha) which has a predicted molecular weight of approximately 40kDa.
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
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Protein Aliases: A inhibin subunit; A-inhibin subunit; IHA; inhibin; Inhibin alpha chain
Gene Aliases: INHA
UniProt ID: (Human) P05111
Entrez Gene ID: (Human) 3623