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|Tested species reactivity||Human, Mouse|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Mouse / IgG1|
|Clone||18P118 (same as DCS-118)|
|Immunogen||Recombinant full length protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay dependent|
|Immunoprecipitation (IP)||1-2 µg/mg|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
MA1-91727 detects INK4c from mouse, human samples.
MA1-91727 has been successfully used in immunofluorescence, immunohistochemistry (paraffin tissue), immunoprecipitation, Western blot applications.
The MA1-91727 immunogen is: Recombinant full length protein
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
An opposite effect of the CDK inhibitor, p18(INK4c) on embryonic stem cells compared with tumor and adult stem cells.
MA1-91727 was used in western blot to study the different effects of p18(INK4c) on embryonic stem cells as opposed to adult stem cells and tumor cells and the therapeutic significance
|Li Y,Pal R,Sung LY,Feng H,Miao W,Cheng SY,Tian C,Cheng T||PloS one (7:null)||2012|
Proliferation and differentiation in isogenic populations of peripheral B cells activated by Epstein-Barr virus or T cell-derived mitogens.
MA1-91727 was used in western blot to study the different proliferation and differentiation of peripheral B-cells following activation with either EBV or CD40L plus IL-4
|O'Nions J,Allday MJ||The Journal of general virology (85:881)||2004|
CDK6 inhibitor p18; cyclin-dependent inhibitor; cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase 6 inhibitor p18; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); INK4C; p18-INK4C; p18-INK6
C77269; CDKN2C; CDKN6; INK4C; p18; p18-INK4C; p18-INK6; p18INK4c