Recommended positive controls: H1299, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (87%), Rat (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
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Protein Aliases: 4; 5-trisphosphate 5-phosphatase; 5PTase; 75 kDa inositol polyphosphate-5-phosphatase; inositol polyphosphate-5-phosphatase, 75kDa; Phosphoinositide 5-phosphatase; RP11-109P14.7; Type II inositol 1,4,5-trisphosphate 5-phosphatase; type II inositol-1
Gene Aliases: 5PTase; INPP5B; OCRL2
UniProt ID: (Human) P32019
Entrez Gene ID: (Human) 3633