The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Inositol and phosphatidylinositol phosphates are important for numerous cellular processes, including neuronal survival and signal transductions from growth factors, neurotransmitters and G protein coupled receptors. INPP5J (inositol polyphosphate-5-phosphatase J), also known as phosphatidylinositol 4,5-bisphosphate 5-phosphatase A, PIPP (proline-rich inositol polyphosphate 5-phosphatase), PIB5PA or INPP5, is a 1,006 amino acid cytoplasmic protein that assists in the conversion of inositol 1,4-bisphosphate from inositol 1,4,5-trisphosphate. Expressed in lung, stomach, kidney, brain, small intestine and heart, INPP5J localizes to membrane ruffles, where it may also participate in modulating inositol and phosphatidylinositol polyphosphate-binding proteins. Encoded by a gene located on human chromosome 22, INPP5J undergoes alternative splicing to produce three isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Inositol polyphosphate 5-phosphatase J; INPP5J; phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; PIB5PA; PIPP; Proline-rich inositol polyphosphate 5-phosphatase
Gene Aliases: Inpp; INPP5; INPP5J; PIB5PA; PIPP