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Product Details
A302-158A-T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Between 2708 and 2758
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
Target Information
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases:
Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; InsP3R type I; insP3R1; InsP>3
Gene Aliases: ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; InsP3R; INSP3R1; IP3R; IP3R1; Itpr-1; ITPR1; opt; P400; Pcd6; Pcp-1; Pcp1; PPP1R94; SCA15; SCA16; SCA29
UniProt ID: (Human) Q14643, (Mouse) P11881
Entrez Gene ID: (Human) 3708, (Mouse) 16438
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
protein binding
calcium ion transmembrane transporter activity
calcium-release channel activity
calcium channel inhibitor activity
phosphatidylinositol binding
ion channel activity
calcium channel activity
protein C-terminus binding
protein phosphatase binding
protein complex binding
ligand-gated ion channel
response to hypoxia
calcium ion transport
signal transduction
post-embryonic development
regulation of autophagy
platelet activation
endoplasmic reticulum calcium ion homeostasis
epithelial fluid transport
inositol phosphate-mediated signaling
regulation of insulin secretion
negative regulation of calcium-mediated signaling
voluntary musculoskeletal movement
release of sequestered calcium ion into cytosol
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of cardiac conduction
transport
ion transport
apoptotic process
positive regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
transmembrane transport
calcium ion transmembrane transport
cellular response to cAMP
negative regulation of neuron death
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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