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|Tested species reactivity||Human, Mouse, Non-human primate|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human IRAK4 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/200 - 1/400|
|Immunohistochemistry (IHC)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
MA5-15883 targets IRAK4 in FACS, IHC, and WB applications and shows reactivity with Human, mouse, and Non-human primate samples.
The MA5-15883 immunogen is purified recombinant fragment of human IRAK4 expressed in E. Coli. .
MA5-15883 detects IRAK4 which has a predicted molecular weight of approximately 52kDa.
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
MA5-15883 was used in western blot to identify species-specific preferences in signaling protein use by comprehensive RNAi-based screening of human and mouse TLR pathways
|Sun J,Li N,Oh KS,Dutta B,Vayttaden SJ,Lin B,Ebert TS,De Nardo D,Davis J,Bagirzadeh R,Lounsbury NW,Pasare C,Latz E,Hornung V,Fraser ID||Science signaling (9:null)||2016|
Interleukin-1 receptor-associated kinase 4; IPD1; IRAK-4; NY-REN-64; REN64; Renal carcinoma antigen NY-REN-64
8430405M07Rik; 9330209D03Rik; IPD1; IRAK-4; IRAK4; NY-REN-64; REN64