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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 295 of IRS1 (Uniprot ID#P35568)|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-34655 targets IRS1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-34655 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 295 of IRS1 (Uniprot ID#P35568).
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
HIRS-1; Insulin receptor substrate 1; IRS-1