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Invitrogen

IRS1 Monoclonal Antibody (K.346.8)

View all (48) IRS1 antibodies
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
433BB748-DC81-4FE4-83AD-384F97313745 Created with sketchtool. Create Citation
C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
433BB748-DC81-4FE4-83AD-384F97313745 Created with sketchtool. Create Citation
C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support

Product Details

Tested Applications
Dilution
Western Blot (WB)
1:1000
Product Specifications
Species Reactivity
Human, Mouse, Pig, Rat
Host / Isotype
Rabbit / IgG
Class
Monoclonal
Type
Antibody
Clone
K.346.8
Immunogen
Synthetic peptide corresponding to the sequence surrounding pSer307 of human IRS-1
Conjugate
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
RRID
AB_10988670

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with IRS-2.

Target Information

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Insulin receptor substrate 1; IRS-1; pp185

Gene Aliases: G972R; HIRS-1; IRS-1; IRS1; IRS1IRM

UniProt ID: (Human) P35568, (Rat) P35570, (Mouse) P35569

Entrez Gene ID: (Human) 3667, (Pig) 100512686, (Rat) 25467, (Mouse) 16367

Function(s)
MAPK cascade signal transduction positive regulation of cell proliferation insulin receptor signaling pathway positive regulation of glucose metabolic process phosphatidylinositol 3-kinase signaling regulation of phosphatidylinositol 3-kinase signaling positive regulation of fatty acid beta-oxidation response to insulin cellular response to insulin stimulus phosphatidylinositol-3-phosphate biosynthetic process glucose homeostasis response to peptide hormone positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity positive regulation of glycogen biosynthetic process positive regulation of glucose import negative regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway negative regulation of insulin secretion phosphatidylinositol phosphorylation insulin-like growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of glucose import in response to insulin stimulus positive regulation of mesenchymal cell proliferation regulation of gene expression lipid catabolic process insulin secretion positive regulation of cell migration mammary gland development response to caffeine protein localization to nucleus positive regulation of phosphorylation protein kinase B signaling protein heterooligomerization positive regulation of glucagon secretion negative regulation of somatostatin secretion
Process(es)
signal transducer activity transmembrane receptor protein tyrosine kinase adaptor activity protein kinase C binding Ras guanyl-nucleotide exchange factor activity insulin receptor binding insulin-like growth factor receptor binding protein binding 1-phosphatidylinositol-3-kinase activity SH2 domain binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein kinase binding protein domain specific binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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