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|Tested species reactivity||Rat|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Rat Splenic PHA blasts|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.1 ug/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17453 targets CD11a/ITGAL/integrin alpha L in FACS applications and shows reactivity with Rat samples.
The MA5-17453 immunogen is rat Splenic PHA blasts.
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
antigen CD11A p180; integrin alpha-L; LFA-1 alpha; LFA-1A; lymphocyte function-associated antigen 1 alpha polypeptide; lymphocyte function-associated antigen-1