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|Tested species reactivity||Human, Mouse, Rabbit|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b|
|Immunogen||T cell enriched splenocytes from B10 mice.|
|Storage buffer||PBS with sucrose|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Neat-1:5|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 13 publications below|
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
The recommended shelf-life for this product is 6 months.
CD11b, also known as the alpha M integrin chain or MAC-1, is a differentiation antigen expressed by granulocytes, monocytes, NK cells and tissue macrophages. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Passive transfer of flt-3L-derived dendritic cells delays diabetes development in NOD mice and associates with early production of interleukin (IL)-4 and IL-10 in the spleen of recipient mice.
MA5-16804 was used in flow cytometry to assess the contribution of DC function in non-obese diabetic mice.
|Morin J,Faideau B,Gagnerault MC,Lepault F,Boitard C,Boudaly S||Clinical and experimental immunology (134:388)||2003|
Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity.
MA5-16804 was used in flow cytometry to use the BALB-neuT model to study carcinogenesis.
|Melani C,Chiodoni C,Forni G,Colombo MP||Blood (102:2138)||2003|
Hematopoietic origin of glomerular mesangial cells.
MA5-16804 was used in flow cytometry to test if hematopoietic stem cells are capable of reconstituting mesangial cells.
|Masuya M,Drake CJ,Fleming PA,Reilly CM,Zeng H,Hill WD,Martin-Studdard A,Hess DC,Ogawa M||Blood (101:2215)||2003|
Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells.
MA5-16804 was used in flow cytometry to test if the survival of a cornea graft is dependent on CD1d-reactive NKT cells.
|Sonoda KH,Taniguchi M,Stein-Streilein J||Journal of immunology (Baltimore, Md. : 1950) (168:2028)||2002|
IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis.
MA5-16804 was used in flow cytometry to investigate IL-12p40-dependent but IL-12p75-independent immune responses in mice infected with Salmonella enteritidis.
|Lehmann J,Bellmann S,Werner C,Schröder R,Schütze N,Alber G||Journal of immunology (Baltimore, Md. : 1950) (167:5304)||2001|
Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle.
MA5-16804 was used in flow cytometry to characterize skeletal muscle hematopoietic progenitors.
|Kawada H,Ogawa M||Blood (98:2008)||2001|
Acquired immunity to Chlamydia pneumoniae is dependent on gamma interferon in two mouse strains that initially differ in this respect after primary challenge.
MA5-16804 was used in flow cytometry to examine the role of gamma interferon in a Chlamydia pneumoniae mouse model.
|Vuola JM,Puurula V,Anttila M,Mäkelä PH,Rautonen N||Infection and immunity (68:960)||2000|
Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice.
MA5-16804 was used in flow cytometry to determine the phenotype and function of T cells that prevent diabetes.
|Lepault F,Gagnerault MC||Journal of immunology (Baltimore, Md. : 1950) (164:240)||2000|
Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow.
MA5-16804 was used in flow cytometry to identify a rare population of cells in the adult mouse bone marrow that generates CD4(+) and CD8(+) TCRalphabeta(+) T cells.
|Dejbakhsh-Jones S,Strober S||Proceedings of the National Academy of Sciences of the United States of America (96:14493)||1999|
CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site.
MA5-16804 was used in flow cytometry to investigate the role of NKT cells in the development of tolerance.
|Sonoda KH,Exley M,Snapper S,Balk SP,Stein-Streilein J||The Journal of experimental medicine (190:1215)||1999|
Gene therapy of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for Fas ligand.
MA5-16804 was used in flow cytometry to study FasL expression on thyrocytes.
|Batteux F,Tourneur L,Trebeden H,Charreire J,Chiocchia G||Journal of immunology (Baltimore, Md. : 1950) (162:603)||1999|
The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors.
MA5-16804 was used in flow cytometry to assess the expression of the T1 surface antigen in murine hemopoietic organs.
|Moritz DR,Rodewald HR,Gheyselinck J,Klemenz R||Journal of immunology (Baltimore, Md. : 1950) (161:4866)||1998|
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.
MA5-16804 was used in flow cytometry to report that TAN1 is an oncoprotein.
|Pear WS,Aster JC,Scott ML,Hasserjian RP,Soffer B,Sklar J,Baltimore D||The Journal of experimental medicine (183:2283)||1996|
antigen CD11b (p170); CD11 antigen-like family member B; CD11B; CD11B (p170); cell surface glycoprotein MAC-1 alpha subunit; Cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component receptor 3 alpha-a; complement receptor type 3; CR-3 alpha chain; CR3A; Integrin alpha M; Integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); Leukocyte adhesion receptor MO1; MAC-1; Mac-1 alpha; MAC1A; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6
CD11B; CD11b/CD18; CR3; CR3A; F730045J24Rik; ITGAM; Ly-40; MAC-1; Mac-1a; MAC1; MAC1A; MO1A; SLEB6