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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG2b|
|Immunogen||C57BL/6 spleen cell enriched for T lymphocytes|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17860 targets CD11b/ITGAM/Integrin alpha M in FACS applications and shows reactivity with Mouse samples.
The MA5-17860 immunogen is c57BL/6 spleen cell enriched for T lymphocytes.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague.
MA5-17860 was used in flow cytometry to study inflammatory lesions of pneumonic plague and spatially distinct neutrophil responses
|Stasulli NM,Eichelberger KR,Price PA,Pechous RD,Montgomery SA,Parker JS,Goldman WE||mBio (6:e01530)||2015|
In vivo transcriptional profiling of Yersinia pestis reveals a novel bacterial mediator of pulmonary inflammation.
MA5-17860 was used in flow cytometry to characterize Yersinia pestis as a novel bacterial mediator of pulmonary inflammation due to in vivo transcriptional profiling
|Pechous RD,Broberg CA,Stasulli NM,Miller VL,Goldman WE||mBio (6:e02302)||2015|
|Not Applicable||Not Cited||
Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice.
MA5-17860 was used in flow cytometry to test if mesenchymal stem cells can control graft-vs-host disease
|Sudres M,Norol F,Trenado A,Grégoire S,Charlotte F,Levacher B,Lataillade JJ,Bourin P,Holy X,Vernant JP,Klatzmann D,Cohen JL||Journal of immunology (Baltimore, Md. : 1950) (176:7761)||2006|
|Not Applicable||Not Cited||
Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses.
MA5-17860 was used in flow cytometry to demonstrate that AChE-R and ARP facilitate granulocytosis
|Grisaru D,Pick M,Perry C,Sklan EH,Almog R,Goldberg I,Naparstek E,Lessing JB,Soreq H,Deutsch V||Journal of immunology (Baltimore, Md. : 1950) (176:27)||2006|
|Not Applicable||Not Cited||
Butyric acid derivative induces allospecific T cell anergy and prevents graft-versus-host disease.
MA5-17860 was used in flow cytometry to test if n-butyrate 2-(4-morpholinyl) ethyl butyrate hydrochloride inactivates the alloantigen-specific T cells that mediate graft-versus-host-disease
|Gilbert KM,Boger S,Fifer EK||Immunopharmacology and immunotoxicology (25:13)||2003|
Passive transfer of flt-3L-derived dendritic cells delays diabetes development in NOD mice and associates with early production of interleukin (IL)-4 and IL-10 in the spleen of recipient mice.
MA5-17860 was used in flow cytometry to assess the contribution of DC function in non-obese diabetic mice.
|Morin J,Faideau B,Gagnerault MC,Lepault F,Boitard C,Boudaly S||Clinical and experimental immunology (134:388)||2003|
Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity.
MA5-17860 was used in flow cytometry to use the BALB-neuT model to study carcinogenesis.
|Melani C,Chiodoni C,Forni G,Colombo MP||Blood (102:2138)||2003|
Hematopoietic origin of glomerular mesangial cells.
MA5-17860 was used in flow cytometry to test if hematopoietic stem cells are capable of reconstituting mesangial cells.
|Masuya M,Drake CJ,Fleming PA,Reilly CM,Zeng H,Hill WD,Martin-Studdard A,Hess DC,Ogawa M||Blood (101:2215)||2003|
Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells.
MA5-17860 was used in flow cytometry to test if the survival of a cornea graft is dependent on CD1d-reactive NKT cells.
|Sonoda KH,Taniguchi M,Stein-Streilein J||Journal of immunology (Baltimore, Md. : 1950) (168:2028)||2002|
IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis.
MA5-17860 was used in flow cytometry to investigate IL-12p40-dependent but IL-12p75-independent immune responses in mice infected with Salmonella enteritidis.
|Lehmann J,Bellmann S,Werner C,Schröder R,Schütze N,Alber G||Journal of immunology (Baltimore, Md. : 1950) (167:5304)||2001|
Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle.
MA5-17860 was used in flow cytometry to characterize skeletal muscle hematopoietic progenitors.
|Kawada H,Ogawa M||Blood (98:2008)||2001|
Acquired immunity to Chlamydia pneumoniae is dependent on gamma interferon in two mouse strains that initially differ in this respect after primary challenge.
MA5-17860 was used in flow cytometry to examine the role of gamma interferon in a Chlamydia pneumoniae mouse model.
|Vuola JM,Puurula V,Anttila M,Mäkelä PH,Rautonen N||Infection and immunity (68:960)||2000|
Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice.
MA5-17860 was used in flow cytometry to determine the phenotype and function of T cells that prevent diabetes.
|Lepault F,Gagnerault MC||Journal of immunology (Baltimore, Md. : 1950) (164:240)||2000|
Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow.
MA5-17860 was used in flow cytometry to identify a rare population of cells in the adult mouse bone marrow that generates CD4(+) and CD8(+) TCRalphabeta(+) T cells.
|Dejbakhsh-Jones S,Strober S||Proceedings of the National Academy of Sciences of the United States of America (96:14493)||1999|
CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site.
MA5-17860 was used in flow cytometry to investigate the role of NKT cells in the development of tolerance.
|Sonoda KH,Exley M,Snapper S,Balk SP,Stein-Streilein J||The Journal of experimental medicine (190:1215)||1999|
Gene therapy of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for Fas ligand.
MA5-17860 was used in flow cytometry to study FasL expression on thyrocytes.
|Batteux F,Tourneur L,Trebeden H,Charreire J,Chiocchia G||Journal of immunology (Baltimore, Md. : 1950) (162:603)||1999|
The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors.
MA5-17860 was used in flow cytometry to assess the expression of the T1 surface antigen in murine hemopoietic organs.
|Moritz DR,Rodewald HR,Gheyselinck J,Klemenz R||Journal of immunology (Baltimore, Md. : 1950) (161:4866)||1998|
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.
MA5-17860 was used in flow cytometry to report that TAN1 is an oncoprotein.
|Pear WS,Aster JC,Scott ML,Hasserjian RP,Soffer B,Sklar J,Baltimore D||The Journal of experimental medicine (183:2283)||1996|
CD11 antigen-like family member B; CD11B; CD11B (p170); cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; CR-3 alpha chain; CR3A; Integrin alpha M; integrin alpha-M; leukocyte adhesion receptor MO1; MAC-1; Mac-1 alpha; MAC1A; macrophage antigen alpha; MGC117044; MO1A; SLEB6
Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1