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|Tested species reactivity||Human, Mouse, Primate, Rabbit|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b|
|Immunogen||B10 mouse spleen cells enriched for T cells|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1 ug/ml|
|Functional Assay (FN)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis.
MA1-10080 was used in flow cytometry to assess the contribution of Tbx1 to thymus and parathyroid development
|Reeh KA,Cardenas KT,Bain VE,Liu Z,Laurent M,Manley NR,Richie ER||Development (Cambridge, England) (141:2950)||2014|
Enhanced resistance against Listeria monocytogenes achieved by pretreatment with granulocyte colony-stimulating factor.
MA1-10080 was used in flow cytometry to study the roles of G-CSF and polymorphonuclear leukocytes in Listeria monocytogenes-infected mice.
|Shinomiya N,Tsuru S,Katsura Y,Kayashima S,Nomoto K||Infection and immunity (59:4740)||1991|
Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity.
MA1-10080 was used in flow cytometry to study regulation of the lck in T cell lineage commitment.
|Shimizu C,Kawamoto H,Yamashita M,Kimura M,Kondou E,Kaneko Y,Okada S,Tokuhisa T,Yokoyama M,Taniguchi M,Katsura Y,Nakayama T||International immunology (13:105)||2001|
Regulation of interleukin-12 by complement receptor 3 signaling.
MA1-10080 was used in blocking assay to show that signaling via CR3 regulates production of interleukin-12.
|Marth T,Kelsall BL||The Journal of experimental medicine (185:1987)||1997|
antigen CD11b (p170); CD11 antigen-like family member B; CD11B; CD11B (p170); cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component receptor 3 alpha-a; complement receptor type 3; CR-3 alpha chain; CR3A; Integrin alpha M; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); leukocyte adhesion receptor MO1; MAC-1; Mac-1 alpha; MAC1A; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; neutrophil adherence receptor alpha-M subunit; SLEB6
CD11B; CD11b/CD18; CR3; CR3A; F730045J24Rik; ITGAM; Ly-40; MAC-1; Mac-1a; MAC1; MAC1A; MO1A; SLEB6