|Tested species reactivity||Human, Mouse, Non-human primate, Rabbit|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG2b|
|Immunogen||B10 mouse spleen cells enriched for T cells|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Chitin induces accumulation in tissue of innate immune cells associated with allergy.
MA1-10082 was used in flow cytometry to characterize the effects of chitin on immune responses
|Reese TA,Liang HE,Tager AM,Luster AD,Van Rooijen N,Voehringer D,Locksley RM||Nature (447:92)||2007|
Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation.
MA1-10082 was used in flow cytometry to examine the role of SOCS-1 in regulating inflammatory and immune responses in acute inflammatory arthritis.
|Egan PJ,Lawlor KE,Alexander WS,Wicks IP||The Journal of clinical investigation (111:915)||2003|
Ligand-activated natural killer T lymphocytes promptly produce IL-3 and GM-CSF in vivo: relevance to peripheral myeloid recruitment.
MA1-10082 was used in flow cytometry to report that activated NKT cells recruit myeloid progenitors and granulocytes to the periphery through their production of hematopoietic growth factors.
|Leite-de-Moraes MC,Lisbonne M,Arnould A,Machavoine F,Herbelin A,Dy M,Schneider E||European journal of immunology (32:1897)||2002|
A peptide derived from bovine beta-casein modulates functional properties of bone marrow-derived macrophages from germfree and human flora-associated mice.
MA1-10082 was used in flow cytometry to report that beta-CN peptide enhances antimicrobial activity of macrophages without proinflammatory effects.
|Sandré C,Gleizes A,Forestier F,Gorges-Kergot R,Chilmonczyk S,Léonil J,Moreau MC,Labarre C||The Journal of nutrition (131:2936)||2001|
Immature multipotent hemopoietic progenitors lacking long-term bone marrow-reconstituting activity in the aorta-gonad-mesonephros region of murine day 10 fetuses.
MA1-10082 was used in flow cytometry to examine multipotent progenitors from early fetuses.
|Ohmura K,Kawamoto H,Lu M,Ikawa T,Ozaki S,Nakao K,Katsura Y||Journal of immunology (Baltimore, Md. : 1950) (166:3290)||2001|
Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver.
MA1-10082 was used in flow cytometry to assess if progenitors colonizing the thymus are T cell lineage restricted.
|Kawamoto H,Ohmura K,Fujimoto S,Katsura Y||Journal of immunology (Baltimore, Md. : 1950) (162:2725)||1999|
A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.
MA1-10082 was used in flow cytometry to use CD44 and CD25 to create T cell subsets and then characterize them.
|Godfrey DI,Kennedy J,Suda T,Zlotnik A||Journal of immunology (Baltimore, Md. : 1950) (150:4244)||1993|