|Flow Cytometry (Flow)||Assay-Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human CD11b (Mac-1)|
|Storage buffer||PBS with BSA, sucrose|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, store in dark|
The TRI-COLOR® conjugate is a tandem R-phycoerythrin (PE)-Cy5® conjugate that permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.
CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X, and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, and blood monocytes. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue.
Analyte Specific Reagent
Protein Aliases: antigen CD11b (p170); CD11 antigen-like family member B; cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; integrin alpha-M; leukocyte adhesion receptor MO1; macrophage antigen alpha polypeptide; neutrophil adherence receptor alpha-M subunit
Gene Aliases: CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6
UniProt ID: (Human) P11215
Entrez Gene ID: (Human) 3684
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