|Tested species reactivity||Rat|
|Published species reactivity||Rat, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Rat Peritoneal Macrophages|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.1 ug/10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17506 targets CD11b/c in FACS, IHC (F), IHC (P), and IP applications and shows reactivity with Rat samples.
The MA5-17506 immunogen is rat Peritoneal Macrophages.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats.
MA5-17506 was used in immunohistochemistry to use the rotenone-induced model of Parkinsonism to explore spinal cord degeneration
|Samantaray S,Knaryan VH,Guyton MK,Matzelle DD,Ray SK,Banik NL||Neuroscience (146:741)||2007|
Priming in the brain, an immunologically privileged organ, elicits anti-tumor immunity.
MA5-17506 was used in immunohistochemistry (frozen) to report successful immunization against a central-nervous-system tumor.
|Fathallah-Shaykh HM,Gao W,Cho M,Herrera MA||International journal of cancer (75:266)||1998|
|Not Applicable||Not Cited||
Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies.
MA5-17506 was used in flow cytometry and immunoprecipitation to characterize expression of rat CD11/CD18
|Tamatani T,Kotani M,Miyasaka M||European journal of immunology (21:627)||1991|