Recommended positive controls: HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (86%), Xenopus laevis (80%), Pig (98%), Chicken (89%), Rhesus Monkey (99%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
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Protein Aliases: FLJ26658; GP3A; integrin beta 5; Integrin beta-5; integrin, beta 5; testis secretory sperm-binding protein Li 217p
Gene Aliases: ITGB5
UniProt ID: (Human) P18084
Entrez Gene ID: (Human) 3693