Product References
B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation.
Nature communications
Stoler-Barak L,Harris E,Peres A,Hezroni H,Kuka M,Di Lucia P,Grenov A,Gurwicz N,Kupervaser M,Yip BH,Iannacone M,Yaari G,Crispino JD,Shulman Z
46-5790-82 was used in Flow cytometry/Cell sorting to demonstrate DYRK1A-mediated biological mechanisms of B cell immune responses that may be used for therapeutic manipulation in antibody-mediated autoimmunity.
Thu Mar 16 00:00:00 EDT 2023
Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.
Nature
Xu J,Xu K,Jung S,Conte A,Lieberman J,Muecksch F,Lorenzi JCC,Park S,Schmidt F,Wang Z,Huang Y,Luo Y,Nair MS,Wang P,Schulz JE,Tessarollo L,Bylund T,Chuang GY,Olia AS,Stephens T,Teng IT,Tsybovsky Y,Zhou T,Munster V,Ho DD,Hatziioannou T,Bieniasz PD,Nussenzweig MC,Kwong PD,Casellas R
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Thu Jul 01 00:00:00 EDT 2021
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
A platform-agnostic, function first-based antibody discovery strategy using plasmid-free mammalian expression of antibodies.
mAbs
Zhang R,Prabakaran P,Yu X,Mackness BC,Boudanova E,Hopke J,Sancho J,Saleh J,Cho H,Zhang N,Simonds-Mannes H,Stimple SD,Hoffmann D,Park A,Chowdhury PS,Rao SP
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Wed Jan 19 00:00:00 EST 2022
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
46-5790-82 was used in Flow Cytometry to demonstrate homotypic and heterotypic conjugation of 8 different hemagglutinin trimers.
Fri Oct 15 00:00:00 EDT 2021
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
46-5790-82 was used in Flow Cytometry to demonstrate homotypic and heterotypic conjugation of 8 different hemagglutinin trimers.
Fri Oct 15 00:00:00 EDT 2021
B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.
Cell reports
Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Tue Feb 11 00:00:00 EST 2020
B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.
Cell reports
Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Tue Feb 11 00:00:00 EST 2020
Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses.
Cell reports
Fallet B,Hao Y,Florova M,Cornille K,de Los Aires AV,Girelli Zubani G,Ertuna YI,Greiff V,Menzel U,Hammad K,Merkler D,Reddy ST,Weill JC,Reynaud CA,Pinschewer DD
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Tue Jan 28 00:00:00 EST 2020
TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
The FEBS journal
Schoeler K,Aufschnaiter A,Messner S,Derudder E,Herzog S,Villunger A,Rajewsky K,Labi V
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Sun Sep 01 00:00:00 EDT 2019
A protocol for generating induced T cells by reprogramming B cells in vivo.
Cell regeneration (London, England)
Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
mTOR has distinct functions in generating versus sustaining humoral immunity.
The Journal of clinical investigation
Jones DD,Gaudette BT,Wilmore JR,Chernova I,Bortnick A,Weiss BM,Allman D
46-5790 was used in Flow cytometry/Cell sorting to conclude that mTOR signalling plays critical but diverse roles in early and late phases of antibody responses and plasma cell differentiation.
Tue Nov 01 00:00:00 EDT 2016
Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program.
Genes & development
Ikawa T,Masuda K,Endo TA,Endo M,Isono K,Koseki Y,Nakagawa R,Kometani K,Takano J,Agata Y,Katsura Y,Kurosaki T,Vidal M,Koseki H,Kawamoto H
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2016
Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
Proceedings of the National Academy of Sciences of the United States of America
Lu G,Duan J,Shu S,Wang X,Gao L,Guo J,Zhang Y
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Tue Feb 02 00:00:00 EST 2016
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system.
Nature communications
Cheong TC,Compagno M,Chiarle R
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Wed Mar 09 00:00:00 EST 2016
Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.
Nature protocols
von Boehmer L,Liu C,Ackerman S,Gitlin AD,Wang Q,Gazumyan A,Nussenzweig MC
46-5790-82 was used in Flow cytometry/Cell sorting to sequence and clone the variable antibody region of single antigen-specific mouse memory B cells for antibody production.
Sat Oct 01 00:00:00 EDT 2016
B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.
Autophagy
Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Mon Apr 18 00:00:00 EDT 2016
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones DD,Wilmore JR,Allman D
46-5790 was used in Flow cytometry/Cell sorting to demonstrate that once established, both IgG-positive and less frequent IgM-positive memory populations are exceptionally stable, with little evidence of attrition or cellular turnover.
Sun Nov 15 00:00:00 EST 2015
Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.
The Journal of experimental medicine
Rouaud P,Saintamand A,Saad F,Carrion C,Lecardeur S,Cogné M,Denizot Y
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Mon May 05 00:00:00 EDT 2014
Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection.
Journal of virology
Jennings RN,Grayson JM,Barton ES
46-5790 was used in Flow cytometry/Cell sorting to assess T cell responses in IFNAR1(-/-) mice after MHV68 infection.
Mon Dec 01 00:00:00 EST 2014
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
eLife
Olive V,Sabio E,Bennett MJ,De Jong CS,Biton A,McGann JC,Greaney SK,Sodir NM,Zhou AY,Balakrishnan A,Foth M,Luftig MA,Goga A,Speed TP,Xuan Z,Evan GI,Wan Y,Minella AC,He L
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Tue Oct 15 00:00:00 EDT 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2013
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine
Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG
46-5790 was used in Flow cytometry/Cell sorting to investigate a functional link between nucleotide deficiency, replication stress, and two enzymes of the nucleoside salvage pathway: deoxycytidine kinase and thymidine kinase.
Mon Nov 19 00:00:00 EST 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2012
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Fri Feb 25 00:00:00 EST 2011
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
Blood
Schuman J,Chen Y,Podd A,Yu M,Liu HH,Wen R,Chen ZJ,Wang D
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Thu May 07 00:00:00 EDT 2009
miR-19 is a key oncogenic component of mir-17-92.
Genes & development
Olive V,Bennett MJ,Walker JC,Ma C,Jiang I,Cordon-Cardo C,Li QJ,Lowe SW,Hannon GJ,He L
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Tue Dec 15 00:00:00 EST 2009
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
Molecular and cellular biology
Bai L,Chen Y,He Y,Dai X,Lin X,Wen R,Wang D
Published figure using IgM monoclonal antibody (Product # 46-5790-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2007