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|Tested species reactivity||Virus|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment of influenza A virus M1 (A/Puerto Rico/8/1934(H1N1))|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
PA5-32253 targets Influenza A Virus M1 in WB applications and shows reactivity with Virus samples.
The PA5-32253 immunogen is recombinant protein fragment of influenza A virus M1 (A/Puerto Rico/8/1934(H1N1)).
Influenza A virus matrix 1, M1, is a critical protein required for assembly and budding. Hemagglutinin associates with M1 via its cytoplasmic tail and transmembrane domain. The M2 and nucleoprotein proteins are critical in the replication cycle of influenza viruses. The M2 channel protein is an essential component of the viral envelope because of its ability to form a highly selective, pH-regulated, proton-conducting channel. The M2 channel allows protons to enter the interior of the virus and acidification weakens the interaction of the M1 protein with the ribonuclear core.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Human nasal epithelial cells derived from multiple subjects exhibit differential responses to H3N2 influenza virus infection in vitro.
PA5-32253 was used in western blot to evaluate the differential responses to H3N2 influenza virus infection in vitro in human nasal epithelial cells derived from multiple subjects
|Yan Y,Tan KS,Li C,Tran T,Chao SS,Sugrue RJ,Shi L,Chow VT,Wang DY||The Journal of allergy and clinical immunology (138:276)||2016|