|Western Blot (WB)||0.5 µg/ml|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Rat|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic Peptide: P(216) C V L D L K M G T R Q H G D D A S(233).|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-906 detects inositol-hexakisphosphate kinase (IP6 kinase) from rat tissues.
PA1-906 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing IP6 kinase from rat brain extract.
PA1-906 immunizing peptide corresponds to amino acid residues 216-233 from human IP6 kinase. PA1-906 immunizing peptide (Cat. # PEP-085) is available for use in neutralization and control experiments.
Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neurotransmitters and, upon binding to the IP3 receptor (IP3R), triggers the release of intracellular, luminal calcium to the cytosol. Several additional cellular forms of inositol phosphates have been discovered. These include some which have been recently discovered and characterized to possess up to seven or eight phosphate groups, including pyrophosphates (PP-IPs: pyrophosphate-inositol phosphates). It has been proposed that high-energy pyrophosphates may participate in protein phosphorylation. Inositol-hexakisphosphate (IP6) kinase, or PiUS (Pi Uptake Stimulator) has ATP synthase activity and transfers a phosphate from PP-IP5 to ADP to form ATP thus suggesting an important physiological role for PP-IP5 and IP6 kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Inositol hexakisphosphate kinase 2; inositol hexaphosphate kinase 2; InsP6 kinase 2; IP6 Kinase; P(i)-uptake stimulator; PiUS
Gene Aliases: Ihpk2; Ip6k2; Pius
UniProt ID: (Rat) Q9R0U1
Entrez Gene ID: (Rat) 59268
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.