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|Tested species reactivity||Bovine, Human, Pig|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified human Insulin.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||1-10 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-10515 detects Insulin from human, bovine, and porcine samples. Antibody will cross react with human proinsulin.
MA1-10515 has been successfully used in ELISA applications.
The MA1-10515 immunogen is purified human Insulin.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Ins; insulin; preproinsulin; proinsulin
BOS_25069; IDDM; IDDM1; IDDM2; ILPR; INS; IRDN; MODY10