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|Tested species reactivity||Human, Pig, Rat|
|Published species reactivity||Rat, Mouse, Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified Insulin protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||0.5-1.0 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-12037 targets Insulin in IHC (P) applications and shows reactivity with Human, Porcine, and Rat samples.
The MA5-12037 immunogen is purified Insulin protein.
Insulin homeostasis; Insulin is a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and tumor (insulinoma) marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The potential role of combined antioxidant treatment on pancreas of STZ-diabetic mice.
MA5-12037 was used in immunohistochemistry to study mitochondrial and cytosolic oxidative stress in streptozotocin-diabetic mouse pancreas and the effect of combined antioxidant therapy
|Karatug A,Bolkent S||Experimental and toxicologic pathology : official journal of the Gesellschaft fu¿r Toxikologische Pathologie (65:255)||2013|
Immunohistochemical expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas.
MA5-12037 was used in immunohistochemistry to study Noc2 expression in normal and tumor tissues of the human endocrine pancreas
|Shanmugam C,Katkoori VR,Jhala NC,Grizzle WE,Manne U||Biotechnic & histochemistry : official publication of the Biological Stain Commission (84:39)||2009|
Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice.
MA5-12037 was used in immunohistochemistry to study the antidiabetic effect of DPP-IV inhibitors and sulfoylureas in mildly diabetic mice
|Matsuyama-Yokono A,Tahara A,Nakano R,Someya Y,Shiraki K,Hayakawa M,Shibasaki M||Metabolism: clinical and experimental (58:379)||2009|
Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes.
MA5-12037 was used in immunohistochemistry to study the antioxidant and pancreas-protective effect of aucubin in streptozotocin-induced diabetes
|Jin L,Xue HY,Jin LJ,Li SY,Xu YP||European journal of pharmacology (582:162)||2008|
Transient in vitro epigenetic reprogramming of skin fibroblasts into multipotent cells.
MA5-12037 was used in immunocytochemistry to study the transient in vitro epigenetic reprogramming of skin fibroblasts into multipotent cells
|Zhu XQ,Pan XH,Wang W,Chen Q,Pang RQ,Cai XM,Hoffman AR,Hu JF||Biomaterials (31:2779)||2010|
insulin; insulin-1; preproinsulin; proinsulin
IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins1; IRDN; MODY10