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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human VLA-1 antigen|
|Storage buffer||PBS with 0.5% BSA|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA49A0 targets CD49a in FACS, IHC(F), IP, and WB applications and shows reactivity with Human samples.
The MA49A0 immunogen is human VLA-1 antigen.
MA49A0 detects CD49a which has a predicted molecular weight of approximately 128 kDa.
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Integrin α1 subunit is up-regulated in colorectal cancer.
MA49A0 was used in immunohistochemistry to study the expression of integrin alpha1 in colorectal cancer
|Boudjadi S,Carrier JC,Beaulieu JF||Biomarker research (1:null)||2013|
Comparative analysis of maternal-fetal interface in preeclampsia and preterm labor.
MA49A0 was used in immunohistochemistry to study the maternal-fetal boundary in preeclampsia and preterm labor
|Zhou Y,Bianco K,Huang L,Nien JK,McMaster M,Romero R,Fisher SJ||Cell and tissue research (329:559)||2007|
Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells.
MA49A0 was used in immunoprecipitation to investigate the biochemical properties of VLA-1 and VLA-2
|Hemler ME,Jacobson JG,Strominger JL||The Journal of biological chemistry (260:15246)||1985|
Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases.
MA49A0 was used in flow cytometry to compare the late activation antigen with the early activation antigen in multiple sclerosis and inflammatory central nervous system diseases
|Hafler DA,Hemler ME,Christenson L,Williams JM,Shapiro HM,Strom TB,Strominger JL,Weiner HL||Clinical immunology and immunopathology (37:163)||1985|
VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation.
MA49A0 was used in flow cytometry to investigate the relationship between the expression of VLA-1 and the activation of human T cells
|Hemler ME,Jacobson JG,Brenner MB,Mann D,Strominger JL||European journal of immunology (15:502)||1985|
CD49 antigen-like family member A; CD49a; integrin alpha 1; Integrin alpha-1; integrin, alpha 1; ITGA1; Laminin and collagen receptor; very late activation protein 1; VLA-1
CD49a; ITGA1; VLA1