|Flow Cytometry (Flow)||1:100 -1:200|
|Tested Species reactivity||Human, Mustelid, Mink, Non-human primate|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human platelet plasma membrane|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
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Protein Aliases: alpha subunit; alphaIIb protein; BDPLT2; CD41; CD41B; GP2B; GPalpha IIb; GPIIb; GTA; HPA3; Integrin alpha-IIb; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGA2B; platelet fibrinogen receptor; platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/IIIa complex; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK; protein phosphatase 1, regulatory subunit 93
Gene Aliases: BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; ITGA2B; ITGAB; PPP1R93
UniProt ID: (Human) P08514
Entrez Gene ID: (Human) 3674
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