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|Tested species reactivity||Many|
|Host / Isotype||Mouse / IgG1|
|Immunogen||JM leukemia line.|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1µg/10^5 cells|
|Functional Assay (FN)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Clone HP2/1 binds to both intact and the 80kDa fragment of integrin alpha-4. This antibody can be used in basic studies of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure and has been demonstrated to inhibit cell binding to soluble VCAM-1.
This product contains sodium azide; removal by dialysis is recommended prior to use in functional assays.
CD49d, also known as integrin alpha-4 or VLA-4 subunit alpha, is a ~150kDa single pass type 1 transmembrane glycoprotein that contains seven FG-GAP repeats, characteristic of alpha integrins, in its extracellular domain. CD49d can be proteolytically cleaved to yield framents of 80 and 70kDa. CD49d associates with either CD29 to form VLA-4 or with Integrin beta-7 to form The Peyer patches-specific homing receptor LPAM-1, involved in the lymphocyte migration and homing to gut-associated lymphoid tissue through its interaction with MadCam-1, preferentially expressed on Peyerâ€™s patch high endothelial venules and postcapillary venules in lamina propria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
269C wild type; alpha 4 subunit of VLA-4 receptor; alpha-4 subunit of VLA-4 receptor; antigen CD49D; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; integrin alpha 4; integrin alpha-4; integrin alpha-IV; integrin alpha4B; ITGA-IV; ITGA4; LPAM subunit alpha; lymphocyte Peyer patch adhesion molecules subunit alpha; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha
CD49D; IA4; ITGA4; Itga4B