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|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b|
|Immunogen||Peyers Patch HEV binding lymphoma line (TK1)|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1.0 ug/10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17805 targets CD49d/Integrin alpha 4 in FACS and IHC (F) applications and shows reactivity with Mouse samples.
The MA5-17805 immunogen is peyers Patch HEV binding lymphoma line (TK1).
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta1, the gut mucosal homing receptor for peripheral T cells. At least two isoforms are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
269C wild type; alpha-4 subunit of VLA-4 receptor; antigen CD49D; CD49 antigen-like family member D; integrin alpha-4; integrin alpha-IV; integrin alpha4B; ITGA-IV; ITGA4; LPAM subunit alpha; lymphocyte Peyer patch adhesion molecules subunit alpha; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha
CD49D; Itga4; Itga4B